Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis.
Behavioral Neuroscience
Cellular Neuroscience
Immunity
Pathophysiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
28 Jun 2019
28 Jun 2019
Historique:
received:
22
10
2018
revised:
09
03
2019
accepted:
09
05
2019
pubmed:
31
5
2019
medline:
31
5
2019
entrez:
31
5
2019
Statut:
ppublish
Résumé
Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases.
Identifiants
pubmed: 31146128
pii: S2589-0042(19)30149-X
doi: 10.1016/j.isci.2019.05.012
pmc: PMC6542186
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12-21Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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