Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine.
etifoxine
mitochondria
mitochondrial permeability transition pore
translocator protein
traumatic brain injury
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2019
29 May 2019
Historique:
received:
27
04
2019
revised:
25
05
2019
accepted:
26
05
2019
entrez:
1
6
2019
pubmed:
31
5
2019
medline:
15
11
2019
Statut:
epublish
Résumé
Experimental studies have shown that ligands of the 18 kDa translocator protein can reduce neuronal damage induced by traumatic brain injury by protecting mitochondria and preventing metabolic crisis. Etifoxine, an anxiolytic drug and 18 kDa translocator protein ligand, has shown beneficial effects in the models of peripheral nerve neuropathy. The present study investigates the potential effect of etifoxine as a neuroprotective agent in traumatic brain injury (TBI). For this purpose, the effect of etifoxine on lesion volume and modified neurological severity score at 4 weeks was tested in Sprague-Dawley adult male rats submitted to cortical impact contusion. Effects of etifoxine treatment on neuronal survival and apoptosis were also assessed by immune stains in the perilesional area. Etifoxine induced a significant reduction in the lesion volume compared to nontreated animals in a dose-dependent fashion with a similar effect on neurological outcome at four weeks that correlated with enhanced neuron survival and reduced apoptotic activity. These results are consistent with the neuroprotective effect of etifoxine in TBI that may justify further translational research.
Identifiants
pubmed: 31146356
pii: ijms20112639
doi: 10.3390/ijms20112639
pmc: PMC6600152
pii:
doi:
Substances chimiques
Carrier Proteins
0
Neuroprotective Agents
0
Oxazines
0
Receptors, GABA-A
0
Tspo protein, rat
141440-82-6
etifoxine
X24X82MX4X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Res. 1999 Feb 15;59(4):831-42
pubmed: 10029072
Life Sci. 1999;64(16):1455-64
pubmed: 10321725
Biochem Pharmacol. 1999 Jul 15;58(2):273-8
pubmed: 10423168
Biochem Biophys Res Commun. 1999 Nov 19;265(2):457-61
pubmed: 10558889
Brain Res. 2000 Mar 24;859(2):255-61
pubmed: 10719072
Stroke. 2001 Apr;32(4):1005-11
pubmed: 11283404
Br J Cancer. 2001 May 18;84(10):1397-404
pubmed: 11355954
Bioorg Med Chem. 2001 Oct;9(10):2661-71
pubmed: 11557354
Leuk Res. 2002 Jan;26(1):91-106
pubmed: 11734307
Br J Cancer. 2001 Nov 30;85(11):1771-80
pubmed: 11742501
Cancer Res. 2002 Mar 1;62(5):1388-93
pubmed: 11888910
J Pathol. 2003 Feb;199(2):221-8
pubmed: 12533835
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3170-4
pubmed: 1373486
J Hepatol. 2004 Nov;41(5):799-807
pubmed: 15519653
Apoptosis. 2005 Jan;10(1):91-104
pubmed: 15711925
Oncogene. 2005 Nov 17;24(51):7503-13
pubmed: 16091749
Pharmacol Biochem Behav. 2005 Dec;82(4):712-20
pubmed: 16388839
J Neurooncol. 2007 Jan;81(1):1-7
pubmed: 16868661
Apoptosis. 2007 May;12(5):835-40
pubmed: 17136322
Cell Calcium. 2007 Jul;42(1):27-39
pubmed: 17174393
J Med Chem. 2007 Jan 25;50(2):404-7
pubmed: 17228885
J Biol Chem. 1991 Feb 25;266(6):3376-9
pubmed: 1847371
Exp Neurol. 2008 Dec;214(2):201-8
pubmed: 18789929
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10
pubmed: 19075249
Clin Exp Pharmacol Physiol. 2009 Jul;36(7):655-61
pubmed: 19076164
Exp Neurol. 2009 Sep;219(1):53-7
pubmed: 19409385
Pain. 2009 Dec 15;147(1-3):54-9
pubmed: 19786322
Oncology. 1990;47(2):139-42
pubmed: 2156202
Pharm Res. 2011 Nov;28(11):2945-53
pubmed: 21584844
J Neuroendocrinol. 2012 Jan;24(1):71-81
pubmed: 21951109
Mol Med Rep. 2013 Jul;8(1):75-80
pubmed: 23670018
EMBO Mol Med. 2013 Jun;5(6):891-903
pubmed: 23681668
Eur J Pain. 2014 Feb;18(2):258-68
pubmed: 23881562
Pain. 2014 Feb;155(2):403-12
pubmed: 24239672
Muscle Nerve. 2014 Aug;50(2):235-43
pubmed: 24273088
Adv Ther. 2015 Jan;32(1):57-68
pubmed: 25620535
Life Sci. 1985 Jan 28;36(4):391-400
pubmed: 2578209
J Neuroinflammation. 2016 Aug 26;13(1):203
pubmed: 27565146
Medicines (Basel). 2018 Feb 05;5(1):null
pubmed: 29401743
Minerva Anestesiol. 2018 May;84(5):632-640
pubmed: 29479930
Life Sci. 1983 Aug 1;33(5):449-57
pubmed: 6308375
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1374-8
pubmed: 7679505
J Neurosurg. 1994 Feb;80(2):291-300
pubmed: 8283269
J Med Chem. 1993 Oct 1;36(20):2908-20
pubmed: 8411007
J Neurotrauma. 1993 Summer;10(2):135-49
pubmed: 8411217
Brain Res. 1996 Apr 22;717(1-2):91-8
pubmed: 8738258
J Med Chem. 1996 Aug 30;39(18):3435-50
pubmed: 8784441
J Med Chem. 1997 Sep 12;40(19):3109-18
pubmed: 9301675
J Med Chem. 1997 Oct 24;40(22):3670-8
pubmed: 9357534
Int J Oncol. 1998 Jun;12(6):1295-8
pubmed: 9592189
Exp Cell Res. 1998 Jun 15;241(2):426-34
pubmed: 9637784
Life Sci. 1998;63(14):1269-80
pubmed: 9771915