Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model.
JNK
apoptosis
esophageal squamous cell carcinoma
galectin-9
microRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2019
29 May 2019
Historique:
received:
24
04
2019
revised:
20
05
2019
accepted:
24
05
2019
entrez:
1
6
2019
pubmed:
31
5
2019
medline:
15
11
2019
Statut:
epublish
Résumé
Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis in various cancers; however, its mechanism of action and bioactivity has not been clarified. We evaluated Gal-9 antitumor effect against esophageal squamous cell carcinoma (ESCC) to analyze the dynamics of apoptosis-related molecules, elucidate its mechanism of action, and identify relevant changes in miRNA expressions. KYSE-150 and KYSE-180 cells were treated with Gal-9 and their proliferation was evaluated. Gal-9 inhibited cell proliferation in a concentration-dependent manner. The xenograft mouse model established with KYSE-150 cells was administered with Gal-9 and significant suppression in the tumor growth observed. Gal-9 treatment of KYSE-150 cells increased the number of Annexin V-positive cells, activation of caspase-3, and collapse of mitochondrial potential, indicating apoptosis induction. c-Jun NH
Identifiants
pubmed: 31146370
pii: ijms20112634
doi: 10.3390/ijms20112634
pmc: PMC6600680
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Galectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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