Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity.
Angiogenesis Inhibitors
/ pharmacology
Animals
Antineoplastic Agents
/ pharmacology
Biocompatible Materials
/ pharmacology
Cell Death
/ drug effects
Cell Line, Tumor
Cell Membrane
/ drug effects
Chickens
Chorioallantoic Membrane
/ drug effects
Docetaxel
/ pharmacology
Human Umbilical Vein Endothelial Cells
/ drug effects
Humans
Nanoparticles
/ chemistry
Neovascularization, Physiologic
/ drug effects
Peptides
/ chemistry
Polyesters
/ chemical synthesis
Polyethylene Glycols
/ chemical synthesis
Vascular Endothelial Growth Factor Receptor-1
/ metabolism
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
18
02
2019
revised:
27
03
2019
accepted:
18
04
2019
entrez:
1
6
2019
pubmed:
31
5
2019
medline:
21
12
2019
Statut:
ppublish
Résumé
Inhibition of tumor angiogenesis is considered as a valuable clinical strategy to treat some tumors, although benefits in term of progression-free and overall survival have been modest. Recent findings have pushed toward the use of antiangiogenic drugs in combination with chemotherapy regimens to potentiate therapeutic outcome. Herein, we propose a novel type of biodegradable antiangiogenic core-shell polymeric nanoparticles (NPs) for the delivery of poorly water-soluble chemotherapeutics. An amphiphilic diblock copolymer of poly(ethyleneglycol)-poly(ε-caprolactone) (PEG-PCL) was conjugated with an anti-FLT1 hexapeptide (aFLT1) at -OH PEG end, mixed in appropriate ratios with a monomethoxy-PEG-PCL and nanoprecipitated to form core-shell aFLT1-bearing NPs (DBL
Identifiants
pubmed: 31147059
pii: S0928-4931(19)30633-2
doi: 10.1016/j.msec.2019.04.054
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Antineoplastic Agents
0
Biocompatible Materials
0
Peptides
0
Polyesters
0
Docetaxel
15H5577CQD
polycaprolactone
24980-41-4
Polyethylene Glycols
3WJQ0SDW1A
Vascular Endothelial Growth Factor Receptor-1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
876-886Informations de copyright
Copyright © 2019. Published by Elsevier B.V.