Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.
consciousness
cortex
hippocampus
hypothalamus
ion channel
memory
Journal
Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
04
12
2018
revised:
11
04
2019
accepted:
03
05
2019
pubmed:
31
5
2019
medline:
8
7
2020
entrez:
1
6
2019
Statut:
ppublish
Résumé
Significant progress has been made in the 21st century towards a comprehensive understanding of the mechanisms of action of general anesthetics, coincident with progress in structural biology and molecular, cellular, and systems neuroscience. This review summarizes important new findings that include target identification through structural determination of anesthetic binding sites, details of receptors and ion channels involved in neurotransmission, and the critical roles of neuronal networks in anesthetic effects on memory and consciousness. These recent developments provide a comprehensive basis for conceptualizing pharmacological control of amnesia, unconsciousness, and immobility.
Identifiants
pubmed: 31147199
pii: S0165-6147(19)30095-1
doi: 10.1016/j.tips.2019.05.001
pmc: PMC6830308
mid: NIHMS1056503
pii:
doi:
Substances chimiques
Anesthetics, General
0
Receptors, GABA-A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
464-481Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM118269
Pays : United States
Organisme : CIHR
ID : FDN-154312
Pays : Canada
Organisme : NIGMS NIH HHS
ID : R01 GM107117
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM055876
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM088156
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM058055
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126155
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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