Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against
Animals
Apoptosis
/ physiology
Caspase 8
/ metabolism
Cell Line
Cytokines
/ metabolism
Inflammasomes
/ metabolism
Inflammation
/ metabolism
Interleukin-12
/ metabolism
Interleukin-1beta
/ metabolism
Mice
Mice, Inbred C57BL
NF-kappa B
/ metabolism
Proto-Oncogene Proteins c-rel
/ metabolism
Signal Transduction
/ physiology
Toxoplasma
/ pathogenicity
Toxoplasmosis
/ metabolism
IL-12
TLR signaling
Toxoplasma
c-Rel
caspase-8
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 06 2019
11 06 2019
Historique:
pubmed:
31
5
2019
medline:
21
3
2020
entrez:
1
6
2019
Statut:
ppublish
Résumé
Caspase-8 is a key integrator of cell survival and cell death decisions during infection and inflammation. Following engagement of tumor necrosis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-extrinsic apoptosis while inhibiting RIPK3-dependent programmed necrosis. In addition, caspase-8 has an important, albeit less well understood, role in cell-intrinsic inflammatory gene expression. Macrophages lacking caspase-8 or the adaptor FADD have defective inflammatory cytokine expression and inflammasome priming in response to bacterial infection or TLR stimulation. How caspase-8 regulates cytokine gene expression, and whether caspase-8-mediated gene regulation has a physiological role during infection, remain poorly defined. Here we demonstrate that both caspase-8 enzymatic activity and scaffolding functions contribute to inflammatory cytokine gene expression. Caspase-8 enzymatic activity was necessary for maximal expression of
Identifiants
pubmed: 31147458
pii: 1820529116
doi: 10.1073/pnas.1820529116
pmc: PMC6575527
doi:
Substances chimiques
Cytokines
0
Inflammasomes
0
Interleukin-1beta
0
NF-kappa B
0
Proto-Oncogene Proteins c-rel
0
REL protein, human
0
Interleukin-12
187348-17-0
CASP8 protein, human
EC 3.4.22.-
Caspase 8
EC 3.4.22.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
11926-11935Subventions
Organisme : NIAID NIH HHS
ID : R21 AI125924
Pays : United States
Organisme : Medical Research Council
ID : MR/J001899/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R21 AI126042
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128530
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139102
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI041158
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Int Immunol. 1999 Mar;11(3):361-71
pubmed: 10221648
J Immunol. 2000 Jul 15;165(2):628-31
pubmed: 10878333
Immunity. 2000 Jun;12(6):633-42
pubmed: 10894163
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12705-10
pubmed: 11058167
Nat Immunol. 2001 Jan;2(1):51-7
pubmed: 11135578
Annu Rev Immunol. 2002;20:197-216
pubmed: 11861602
Nature. 2002 Sep 26;419(6905):395-9
pubmed: 12353035
Science. 2002 Nov 8;298(5596):1241-5
pubmed: 12424381
Cell. 2002 Dec 27;111(7):927-30
pubmed: 12507420
Infect Immun. 2003 Mar;71(3):1513-9
pubmed: 12595470
Mol Cell. 2003 Jun;11(6):1563-74
pubmed: 12820969
Eur J Immunol. 2003 Jul;33(7):1998-2006
pubmed: 12884866
J Immunol. 2003 Oct 15;171(8):4294-303
pubmed: 14530354
EMBO J. 2003 Oct 15;22(20):5530-9
pubmed: 14532125
J Immunol. 2004 Sep 1;173(5):2976-84
pubmed: 15322156
Science. 2005 Mar 4;307(5714):1465-8
pubmed: 15746428
J Immunol. 2005 Apr 15;174(8):4942-52
pubmed: 15814722
J Exp Med. 2005 Jun 6;201(11):1761-9
pubmed: 15928200
J Biol Chem. 2005 Dec 23;280(51):41827-34
pubmed: 16246838
J Biol Chem. 2007 Mar 9;282(10):7416-23
pubmed: 17213198
Cell Death Differ. 2007 Mar;14(3):400-10
pubmed: 17301840
Curr Biol. 2007 Mar 6;17(5):418-24
pubmed: 17306544
Cell. 2008 Feb 8;132(3):344-62
pubmed: 18267068
J Immunol. 2008 Aug 15;181(4):2522-32
pubmed: 18684943
Immunity. 2010 Mar 26;32(3):317-28
pubmed: 20206554
Cell Host Microbe. 2010 May 20;7(5):376-87
pubmed: 20478539
Blood. 2010 Dec 16;116(25):5580-8
pubmed: 20855868
Int Immunol. 2010 Nov;22(11):851-61
pubmed: 21118906
Biochem J. 2011 Feb 1;433(3):447-457
pubmed: 21235526
Nature. 2011 Mar 17;471(7338):368-72
pubmed: 21368762
Nature. 2011 Mar 17;471(7338):363-7
pubmed: 21368763
J Exp Med. 2011 Apr 11;208(4):633-41
pubmed: 21402742
Mol Cell. 2011 Aug 5;43(3):432-48
pubmed: 21737329
Mol Cell. 2011 Aug 5;43(3):449-63
pubmed: 21737330
Immunity. 2011 Aug 26;35(2):249-59
pubmed: 21867928
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7
pubmed: 21876153
Cell Host Microbe. 2011 Sep 15;10(3):224-36
pubmed: 21925110
Nat Cell Biol. 2011 Oct 30;13(12):1437-42
pubmed: 22037414
Nat Immunol. 2011 Nov 20;13(1):95-102
pubmed: 22101729
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20054-9
pubmed: 22123964
Cell Death Differ. 2012 Oct;19(10):1709-21
pubmed: 22555457
Cell Rep. 2012 May 31;1(5):401-7
pubmed: 22675671
Mol Cell. 2012 Jul 27;47(2):291-305
pubmed: 22683266
Nature. 2013 Sep 12;501(7466):247-51
pubmed: 24025841
PLoS One. 2013 Oct 02;8(10):e76841
pubmed: 24098568
J Immunol. 2013 Nov 15;191(10):5239-46
pubmed: 24123685
J Immunol. 2014 Feb 15;192(4):1835-46
pubmed: 24453255
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6
pubmed: 24799678
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90
pubmed: 24799700
EMBO Rep. 2014 Sep;15(9):982-90
pubmed: 24990442
Infect Immun. 2014 Oct;82(10):4056-67
pubmed: 25024368
J Immunol. 2014 Sep 1;193(5):2519-2530
pubmed: 25063877
Cell Rep. 2014 Sep 11;8(5):1308-17
pubmed: 25159141
Cold Spring Harb Perspect Biol. 2015 Apr 01;7(4):null
pubmed: 25833847
Immunity. 2015 Jun 16;42(6):1130-42
pubmed: 26070484
Nat Commun. 2015 Jun 24;6:7515
pubmed: 26104484
Mol Cell. 2015 Oct 1;60(1):63-76
pubmed: 26344099
Nat Immunol. 2016 Jan;17(1):26-33
pubmed: 26681459
Mol Cell. 2016 Mar 17;61(6):834-49
pubmed: 26990987
Cell Rep. 2016 Jun 14;15(11):2449-61
pubmed: 27264187
Cell Host Microbe. 2016 Jul 13;20(1):13-24
pubmed: 27321907
J Immunol. 2016 Nov 15;197(10):4110-4117
pubmed: 27733552
PLoS Pathog. 2016 Oct 13;12(10):e1005910
pubmed: 27737018
Nat Microbiol. 2017 Jan 13;2:16258
pubmed: 28085133
Mol Cell. 2017 Feb 16;65(4):715-729.e5
pubmed: 28212752
J Exp Med. 2017 Nov 6;214(11):3171-3182
pubmed: 28855241
Science. 2018 Nov 30;362(6418):1064-1069
pubmed: 30361383
J Exp Med. 2018 Dec 3;215(12):3136-3150
pubmed: 30442645
Mol Cell. 2019 Feb 7;73(3):413-428.e7
pubmed: 30598363
J Biol Chem. 1995 Apr 7;270(14):7795-8
pubmed: 7536190
Mol Cell Biol. 1995 Oct;15(10):5258-67
pubmed: 7565674
Immunology. 1995 Jan;84(1):16-20
pubmed: 7890300
Infect Immun. 1994 Jul;62(7):2818-24
pubmed: 7911785
Immunity. 1996 May;4(5):471-81
pubmed: 8630732
Cell. 1996 Jun 14;85(6):803-15
pubmed: 8681376
Cell. 1996 Jun 14;85(6):817-27
pubmed: 8681377
EMBO J. 1997 Mar 17;16(6):1413-26
pubmed: 9135156
Nature. 1997 Jul 10;388(6638):190-5
pubmed: 9217161
Cell. 1998 Aug 21;94(4):491-501
pubmed: 9727492