Hypoxia induces the dormant state in oocytes through expression of
Foxo3
hypoxia
oocytes
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 06 2019
18 06 2019
Historique:
pubmed:
31
5
2019
medline:
27
3
2020
entrez:
1
6
2019
Statut:
ppublish
Résumé
In mammals, most immature oocytes remain dormant in the primordial follicles to ensure the longevity of female reproductive life. A precise understanding of mechanisms underlying the dormancy is important for reproductive biology and medicine. In this study, by comparing mouse oogenesis in vivo and in vitro, the latter of which bypasses the primordial follicle stage, we defined the gene-expression profile representing the dormant state of oocytes. Overexpression of constitutively active FOXO3 partially reproduced the dormant state in vitro. Based on further gene-expression analysis, we found that a hypoxic condition efficiently induced the dormant state in vitro. The effect of hypoxia was severely diminished by disruption of the
Identifiants
pubmed: 31147464
pii: 1817223116
doi: 10.1073/pnas.1817223116
pmc: PMC7056940
doi:
Substances chimiques
Forkhead Box Protein O3
0
FoxO3 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12321-12326Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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