ANO1/TMEM16A regulates process maturation in radial glial cells in the developing brain.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
18 06 2019
Historique:
pubmed: 31 5 2019
medline: 9 4 2020
entrez: 1 6 2019
Statut: ppublish

Résumé

Neural stem cells (NSCs) are primary progenitor cells in the early developmental stage in the brain that initiate a diverse lineage of differentiated neurons and glia. Radial glial cells (RGCs), a type of neural stem cell in the ventricular zone, are essential for nurturing and delivering new immature neurons to the appropriate cortical target layers. Here we report that Anoctamin 1 (ANO1)/TMEM16A, a Ca

Identifiants

pubmed: 31147466
pii: 1901067116
doi: 10.1073/pnas.1901067116
pmc: PMC6589654
doi:

Substances chimiques

ANO1 protein, mouse 0
Anoctamin-1 0
Bdnf protein, mouse 0
Brain-Derived Neurotrophic Factor 0
Chlorides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12494-12499

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Gyu-Sang Hong (GS)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea.

Sung Hoon Lee (SH)

College of Pharmacy, Chung-ang University, 06974 Seoul, Korea.

Byeongjun Lee (B)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea.

Jae Hyouk Choi (JH)

Division of Bio-Medical Science and Technology, Korea Institute of Science and Technology, 02792 Seoul, Korea.

Soo-Jin Oh (SJ)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea.

Yongwoo Jang (Y)

Department of Biomedical Engineering, Hanyang University, 04763 Seoul, Korea.

Eun Mi Hwang (EM)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea.
Division of Bio-Medical Science and Technology, Korea Institute of Science and Technology, 02792 Seoul, Korea.

Hyungsup Kim (H)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea.

Jooyoung Jung (J)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea.

In-Beom Kim (IB)

Department of Anatomy, College of Medicine, Catholic University, 06591 Seoul, Korea.

Uhtaek Oh (U)

Brain Science Institute, Korea Institute of Science and Technology, 02792 Seoul, Korea; utoh@kist.re.kr.

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