Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.
Animals
Antiviral Agents
/ therapeutic use
Arenaviridae Infections
/ drug therapy
Cell Proliferation
/ radiation effects
Cells, Cultured
Cellular Senescence
/ genetics
Cyclin-Dependent Kinase Inhibitor p16
/ genetics
Ganciclovir
/ therapeutic use
Lymphocytic choriomeningitis virus
/ immunology
Macrophages
/ metabolism
Mice
Mice, Transgenic
Phenotype
Radiation, Ionizing
Rejuvenation
/ physiology
Spleen
/ metabolism
T-Lymphocytes
/ immunology
T cell
ionizing radiation
p16INK4a
senescence
senescent-associated secretory phenotype
spleen
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
14
06
2018
revised:
16
04
2019
accepted:
06
05
2019
pubmed:
31
5
2019
medline:
8
7
2020
entrez:
1
6
2019
Statut:
ppublish
Résumé
Some studies show eliminating senescent cells rejuvenate aged mice and attenuate deleterious effects of chemotherapy. Nevertheless, it remains unclear whether senescence affects immune cell function. We provide evidence that exposure of mice to ionizing radiation (IR) promotes the senescent-associated secretory phenotype (SASP) and expression of p16
Identifiants
pubmed: 31148373
doi: 10.1111/acel.12971
pmc: PMC6612633
doi:
Substances chimiques
Antiviral Agents
0
Cdkn2a protein, mouse
0
Cyclin-Dependent Kinase Inhibitor p16
0
Ganciclovir
P9G3CKZ4P5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12971Subventions
Organisme : CIHR
ID : MOP-341566
Pays : Canada
Organisme : CIHR
ID : MOP-130469
Pays : Canada
Informations de copyright
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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