Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques.
Diseases
Immunology
Microbiology
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
01
2019
accepted:
03
05
2019
entrez:
1
6
2019
pubmed:
1
6
2019
medline:
1
6
2019
Statut:
epublish
Résumé
Tuberculosis (TB) is the leading cause of death from infection worldwide. The only approved vaccine, BCG, has variable protective efficacy against pulmonary TB, the transmissible form of the disease. Therefore, improving this efficacy is an urgent priority. This study assessed whether heterologous prime-boost vaccine regimens in which BCG priming is boosted with either (i) protein and adjuvant (M72 plus AS01
Identifiants
pubmed: 31149352
doi: 10.1038/s41541-019-0113-9
pii: 113
pmc: PMC6538611
doi:
Types de publication
Journal Article
Langues
eng
Pagination
21Déclaration de conflit d'intérêts
Competing interestsThe authors from University of Pittsburgh, NIH and Aeras have no competing interests. At Statens Serum Institut, Peter Andersen is a coinventor of patents relating to cationic liposomes as vaccine adjuvants and of patents relating to TB fusion protein Ag85B-ESAT-6-Rv2660 (H56). All rights have been assigned to Statens Serum Institut (SSI).
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