Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost.
Diseases
Immunology
Influenza virus
Medical research
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
12
2018
accepted:
03
05
2019
entrez:
1
6
2019
pubmed:
1
6
2019
medline:
1
6
2019
Statut:
epublish
Résumé
Highly pathogenic avian influenza (HPAI) A(H5Nx) viruses continue to pose a pandemic threat. US national vaccine stockpiles are a cornerstone of the influenza pandemic preparedness plans. However, continual genetic and antigenic divergence of A(H5Nx) viruses requires the development of effective vaccination strategies using stockpiled vaccines and adjuvants for pandemic preparedness. Human sera collected from healthy adults who received either homologous (2 doses of a AS03
Identifiants
pubmed: 31149353
doi: 10.1038/s41541-019-0114-8
pii: 114
pmc: PMC6541649
doi:
Types de publication
Journal Article
Langues
eng
Pagination
22Déclaration de conflit d'intérêts
Competing interestsThe following interests are relevant to the submitted work. D.F., P.B., B.L.I, and C.P.M are, or were at the time of the studies, employees of the GSK group of companies. D.F., P.B., and C.P.M. report ownership of GSK shares and/or restricted GSK shares. B.L.I. and C.P.M. are listed as an inventor on patents owned by the GSK group of companies. M. Z. L. C.H., S.J., F.L.G, F.L, T.M.T., J.S., and J.M.K. are employees of CDC; at the time of the study, S.L. was an employee of BARDA.
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