Interaction of the nervous system and vascular system is required for the proper assembly of the neocortex.
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
11
02
2019
revised:
07
05
2019
accepted:
27
05
2019
pubmed:
1
6
2019
medline:
2
6
2020
entrez:
1
6
2019
Statut:
ppublish
Résumé
Mammalian neocortical development encompasses an entire set of events that leads to the generation of excitatory and inhibitory neurons from neural progenitors in the dorsal and ventral telencephalon, including cell proliferation, production of migratory precursors and their progeny, differentiation, and integration into circuits. During these processes, the developing neocortex acquires its vasculature by angiogenesis, a process consisting of proliferation of endothelial cells in existing blood vessels or vascular plexuses, and leading to formation of new blood vessels. Recent studies have suggested that neocortical angiogenesis progresses in a spatially and temporally restricted manner to construct a specialized vascular niche that supports ongoing neurogenesis during neocortical development. Here we review that periventricular blood vessels selectively influence neocortical progenitors behavior and neurogenesis, highlighting how CNS angiogenesis is utilized to construct neocortical cytoarchitecture.
Identifiants
pubmed: 31150772
pii: S0197-0186(19)30090-7
doi: 10.1016/j.neuint.2019.104481
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104481Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.