miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression.
HSF1
hepatic stellate cells
liver fibrosis
miR-455-3p
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
07 Jun 2019
07 Jun 2019
Historique:
received:
14
12
2018
revised:
04
04
2019
accepted:
02
05
2019
pubmed:
1
6
2019
medline:
1
6
2019
entrez:
1
6
2019
Statut:
ppublish
Résumé
Liver fibrosis is a common pathological process of end-stage liver diseases. However, the role of microRNA (miRNA) in liver fibrosis is poorly understood. The activated hepatic stellate cells (HSCs) are the major source of fibrogenic cells and play a central role in liver fibrosis. In this study, we investigated the differential expression of miRNAs in resting and transforming growth factor β1 (TGF-β1) activated HSCs by microarray analysis and found that miR-455-3p was significantly downregulated during HSCs activation. In addition, the reduction of miR-455-3p was correlated with liver fibrosis in mice with carbon tetrachloride (CCl
Identifiants
pubmed: 31150929
pii: S2162-2531(19)30122-2
doi: 10.1016/j.omtn.2019.05.001
pmc: PMC6539335
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
758-769Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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