Longitudinal analysis reveals early-pregnancy associations between perfluoroalkyl sulfonates and thyroid hormone status in a Canadian prospective birth cohort.
Adult
Alkanesulfonates
/ blood
Alkanesulfonic Acids
/ blood
Autoantibodies
/ blood
Canada
Environmental Pollutants
/ blood
Female
Fluorocarbons
/ blood
Humans
Hypothyroidism
/ blood
Longitudinal Studies
Pregnancy
Pregnancy Complications
/ blood
Pregnancy Trimester, Second
Prospective Studies
Thyroid Hormones
/ blood
Thyrotropin
/ blood
Thyroxine
/ blood
Triiodothyronine
/ blood
Longitudinal study design
Perfluoroalkyl acids
Perfluoroalkyl carboxylates
Perfluoroalkyl sulfonates
Pregnancy
Thyroid hormones
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
01
01
2019
revised:
20
03
2019
accepted:
09
04
2019
pubmed:
1
6
2019
medline:
7
11
2019
entrez:
1
6
2019
Statut:
ppublish
Résumé
Serum perfluoroalkyl acids (PFAAs) have been linked to disruption of maternal thyroid hormone homeostasis, but results have varied between studies which we hypothesized was due to timing of the thyroid hormone measurements, variability in PFAA isomer patterns, or presence of other stressors. In a longitudinal study design, we investigated the time-dependency of associations between PFAA isomers and thyroid hormones during pregnancy and post-partum while considering thyroid peroxidase antibody (TPOAb) status and mercury (Hg) co-exposure. In participants of a prospective Canadian birth cohort (n = 494), free thyroxine (FT4), free triiodothyronine (FT3), thyroid stimulating hormone (TSH) and TPOAb were quantified in maternal plasma collected in each trimester and 3-months postpartum, and 25 PFAAs (15 linear and 10 branched) and Hg were quantified in samples collected during the second trimester. Perfluorohexane sulfonate (PFHxS) and total branched isomers of perfluorooctane sulfonate (PFOS) were positively associated with TSH in mixed-effect models, with strongest associations early in gestation. Throughout pregnancy and post-partum, PFHxS was inversely associated with FT4, consistent with elevated TSH, while Hg was inversely associated with FT3. In TPOAb-positive women, negative associations were found between PFUnA and FT4, and 1m-PFOS and TSH, supporting previous studies that thyroid disorder could increase susceptibility to PFAA-mediated hormone dysregulation. Hg did not confound associations but was a significant interaction term, revealing further positive associations between PFOS isomers (∑3m+4m-PFOS) and TSH. Higher perfluoroalkyl sulfonate exposures were associated with higher TSH and/or lower FT4, strongly suggestive that PFHxS and branched PFOS isomers are risk factors for subclinical maternal hypothyroidism. Isomer-specific analysis is important in future studies, as crude measures of 'total-PFOS' masked the associations of branched isomers. A concerning result was for PFHxS which had consistent negative associations with FT4 at all time points and a positive association with TSH in early pregnancy when fetal development is most sensitive to disruption.
Identifiants
pubmed: 31150980
pii: S0160-4120(18)33209-4
doi: 10.1016/j.envint.2019.04.023
pmc: PMC6859374
mid: NIHMS1530736
pii:
doi:
Substances chimiques
Alkanesulfonates
0
Alkanesulfonic Acids
0
Autoantibodies
0
Environmental Pollutants
0
Fluorocarbons
0
Thyroid Hormones
0
thyroid microsomal antibodies
0
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
perfluorooctane sulfonic acid
9H2MAI21CL
perflexane
FX3WJ41CMX
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
389-399Subventions
Organisme : NIEHS NIH HHS
ID : R21 ES021295
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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