Norovirus Attachment and Entry.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
30 05 2019
Historique:
received: 30 04 2019
revised: 24 05 2019
accepted: 25 05 2019
entrez: 2 6 2019
pubmed: 4 6 2019
medline: 10 9 2020
Statut: epublish

Résumé

Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and pathogenesis. Bile salts and histo-blood group antigens are key mediators of norovirus entry; however, the molecular mechanisms by which these molecules promote infection and the identity of a potential human norovirus receptor remain unknown. Recently, there have been several important advances in norovirus entry biology including the identification of CD300lf as the receptor for murine norovirus and of the role of the minor capsid protein VP2 in viral genome release. Here, we will review the current understanding about norovirus attachment and entry and highlight important future directions.

Identifiants

pubmed: 31151248
pii: v11060495
doi: 10.3390/v11060495
pmc: PMC6630345
pii:
doi:

Substances chimiques

Blood Group Antigens 0
CLM-1 protein, mouse 0
Capsid Proteins 0
Receptors, Immunologic 0
Receptors, Virus 0
Viral Structural Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K08 AI128043
Pays : United States
Organisme : NIH HHS
ID : K08 AI128043
Pays : United States

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Auteurs

Vincent R Graziano (VR)

Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. vincent.graziano@yale.edu.

Jin Wei (J)

Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Jin.wei@yale.edu.

Craig B Wilen (CB)

Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. craig.wilen@yale.edu.

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Classifications MeSH