Bringing microbiome-drug interaction research into the clinic.
Animals
Anti-Infective Agents
/ pharmacology
Biodiversity
Computational Biology
/ methods
Gastrointestinal Microbiome
/ drug effects
Humans
Inactivation, Metabolic
Liver
/ metabolism
Metabolic Detoxication, Phase I
Metabolic Detoxication, Phase II
Microbiota
/ drug effects
Translational Research, Biomedical
Drug metabolism
High throughput genomics
Metabolomics
Microbiome
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
05
03
2019
revised:
03
05
2019
accepted:
03
05
2019
pubmed:
4
6
2019
medline:
18
12
2019
entrez:
2
6
2019
Statut:
ppublish
Résumé
Our understanding of the scope and clinical relevance of gut microbiota metabolism of drugs is limited to relatively few biotransformations targeting a subset of therapeutics. Translating microbiome research into the clinic requires, in part, a mechanistic and predictive understanding of microbiome-drug interactions. This review provides an overview of microbiota chemistry that shapes drug efficacy and toxicity. We discuss experimental and computational approaches that attempt to bridge the gap between basic and clinical microbiome research. We highlight the current landscape of preclinical research focused on identifying microbiome-based biomarkers of patient drug response and we describe clinical trials investigating approaches to modulate the microbiome with the goal of improving drug efficacy and safety. We discuss approaches to aggregate clinical and experimental microbiome features into predictive models and review open questions and future directions toward utilizing the gut microbiome to improve drug safety and efficacy.
Identifiants
pubmed: 31151933
pii: S2352-3964(19)30310-X
doi: 10.1016/j.ebiom.2019.05.009
pmc: PMC6604038
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
708-715Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007491
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
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