Adjunctive photodynamic therapy improves the outcomes of peri-implantitis: a randomized controlled trial.
Mechanical debridement
peri-implantitis
photodynamic therapy
randomized controlled trial
Journal
Australian dental journal
ISSN: 1834-7819
Titre abrégé: Aust Dent J
Pays: Australia
ID NLM: 0370612
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
accepted:
29
05
2019
pubmed:
4
6
2019
medline:
4
3
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
Photodynamic therapy (PDT) can be used for the management of peri-implantitis. This study aimed to explore the efficacy and safety of PDT for peri-implantitis in Chinese Han patients. This was a single-centre, open-label, randomized controlled trial of participants with peri-implantitis treated at the Beijing Chao-Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/mL; 3 min) and a 635-nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3- and 6-month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better (P < 0.05 vs. controls). PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri-implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.
Sections du résumé
BACKGROUND
Photodynamic therapy (PDT) can be used for the management of peri-implantitis. This study aimed to explore the efficacy and safety of PDT for peri-implantitis in Chinese Han patients.
METHODS
This was a single-centre, open-label, randomized controlled trial of participants with peri-implantitis treated at the Beijing Chao-Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/mL; 3 min) and a 635-nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm
RESULTS
PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3- and 6-month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better (P < 0.05 vs. controls).
CONCLUSION
PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri-implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
256-262Informations de copyright
© 2019 Australian Dental Association.
Références
Berglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 2018;45(Suppl 20):S286-S291.
Lindhe J, Lang NP, Berglundh T, Giannobile WV, Sanz M. Clinical periodontology and implant dentistry. Chichester: Wiley Blackwell, 2015.
Prathapachandran J, Suresh N. Management of peri-implantitis. Dent Res J (Isfahan) 2012;9:516-521.
Valente NA, Andreana S. Peri-implant disease: what we know and what we need to know. J Periodontal Implant Sci 2016;46:136-151.
Stacchi C, Berton F, Perinetti G, et al. Risk Factors for Peri-Implantitis: effect of History of Periodontal Disease and Smoking Habits. A Systematic Review and Meta-Analysis. J Oral Maxillofac Res 2016;7:e3.
Pokrowiecki R, Mielczarek A, Zareba T, Tyski S. Oral microbiome and peri-implant diseases: where are we now? Ther Clin Risk Manag 2017;13:1529-1542.
Thurnheer T, Belibasakis GN. Incorporation of staphylococci into titanium-grown biofilms: an in vitro “submucosal” biofilm model for peri-implantitis. Clin Oral Implants Res 2016;27:890-895.
Fransson C, Lekholm U, Jemt T, Berglundh T. Prevalence of subjects with progressive bone loss at implants. Clin Oral Implants Res 2005;16:440-446.
Roos-Jansaker AM, Lindahl C, Renvert H, Nine- Renvert S. to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol 2006;33:290-295.
Atieh MA, Alsabeeha NH, Faggion CM Jr, Duncan WJ. The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol 2013;84:1586-1598.
Wang WC, Lagoudis M, Yeh CW, Paranhos KS. Management of peri-implantitis - A contemporary synopsis. Singapore Dent J 2017;38:8-16.
Hanif A, Qureshi S, Sheikh Z, Rashid H. Complications in implant dentistry. Eur J Dent 2017;11:135-140.
Chen J, Keltner L, Christophersen J, et al. New technology for deep light distribution in tissue for phototherapy. Cancer J 2002;8:154-163.
Josefsen LB, Boyle RW. Photodynamic therapy: novel third-generation photosensitizers one step closer? Br J Pharmacol 2008;154:1-3.
Vohra F, Al-Rifaiy MQ, Lillywhite G, Abu Hassan MI, Javed F. Efficacy of mechanical debridement with adjunct antimicrobial photodynamic therapy for the management of peri-implant diseases: a systematic review. Photochem Photobiol Sci 2014;13:1160-1168.
Abduljabbar T. Effect of mechanical debridement with adjunct antimicrobial photodynamic therapy in the treatment of peri-implant diseases in type-2 diabetic smokers and non-smokers. Photodiagnosis Photodyn Ther 2017;17:111-114.
Abduljabbar T. Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implant diseases in prediabetic patients. Photodiagnosis Photodyn Ther 2017;17:9-12.
Sivaramakrishnan G, Sridharan K. Photodynamic therapy for the treatment of peri-implant diseases: A network meta-analysis of randomized controlled trials. Photodiagnosis Photodyn Ther 2018;21:1-9.
Karimi MR, Hasani A, Khosroshahian S. Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: a Randomized Controlled Clinical Trial. J Lasers Med Sci 2016;7:139-145.
Romeo U, Nardi GM, Libotte F, et al. The Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implantitis. Int J Dent 2016;2016:7692387.
Albaker AM, ArRejaie AS, Alrabiah M, Abduljabbar T. Effect of photodynamic and laser therapy in the treatment of peri-implant mucositis: a systematic review. Photodiagnosis Photodyn Ther 2018;21:147-152.
Al Habashneh R, Asa'ad FA, Khader Y. Photodynamic therapy in periodontal and peri-implant diseases. Quintessence Int 2015;46:677-690.
Al Rifaiy MQ, Qutub OA, Alasqah MN, et al. Effectiveness of adjunctive antimicrobial photodynamic therapy in reducing peri-implant inflammatory response in individuals vaping electronic cigarettes: a randomized controlled clinical trial. Photodiagnosis Photodyn Ther 2018;22:132-136.
Al-Askar M, Al-Kheraif AA, Ahmed HB, et al. Effectiveness of mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of periodontal inflammation among patients with prediabetes. Photodiagnosis Photodyn Ther 2017;20:91-94.
Kotsakis GA, Konstantinidis I, Karoussis IK, Ma X, Chu H. Systematic review and meta-analysis of the effect of various laser wavelengths in the treatment of peri-implantitis. J Periodontol 2014;85:1203-1213.
Bassetti M, Schar D, Wicki B, et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res 2014;25:279-287.
Albaker AM, ArRejaie AS, Alrabiah M, et al. Effect of antimicrobial photodynamic therapy in open flap debridement in the treatment of peri-implantitis: a randomized controlled trial. Photodiagnosis Photodyn Ther 2018;23:71-74.
Schar D, Ramseier CA, Eick S, et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: six-month outcomes of a prospective randomized clinical trial. Clin Oral Implants Res 2013;24:104-110.
Tavares LJ, Pavarina AC, Vergani CE, de Avila ED. The impact of antimicrobial photodynamic therapy on peri-implant disease: what mechanisms are involved in this novel treatment? Photodiagnosis Photodyn Ther 2017;17:236-244.
Brignardello-Petersen R. Insufficient evidence about benefits of antimicrobial photodynamic therapy as an adjunct to mechanic curettage in smokers with peri-implant mucositis. J Am Dent Assoc 2017;148:e114.
Zhou LY, Shi JY, Zhu Y, et al. The effect of photodynamic therapy on pathogenic bacteria around peri-implant sulcus and in the cavity between abutment and implant after healing phase: a prospective clinical study. Lasers Surg Med 2018;50:433-439.