Bowman's topography for improved detection of early ectasia.
Bowman's layer
OCT
aberrations
ectasia
keratoconus
topography
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
04
2019
revised:
08
04
2019
accepted:
31
05
2019
pubmed:
4
6
2019
medline:
10
10
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
The aim of this study was to evaluate whether OCT topography of the Bowman's layer and artificial intelligence (AI) can result in better diagnosis of forme fruste (FFKC) and clinical keratoconus (KC). Normal (n = 221), FFKC (n = 72) and KC (n = 116) corneas were included. Some of the FFKC and KC patients had the fellow eye (VAE-NT) with normal topography (n = 30). The Scheimpflug and OCT scans of the cornea were analyzed. The curvature and surface aberrations (ray tracing) of the anterior corneal surface [air-epithelium (A-E) interface in OCT] and epithelium-Bowman's layer (E-B) interface (in OCT only) were calculated. Four random forest models were constructed: (1) Scheimpflug only; (2) OCT A-E only; (3) OCT E-B only; (4) OCT A-E and E-B combined. For normal eyes, both Scheimpflug and OCT (A-E and E-B combined) performed equally in identifying these eyes (P = .23). However, OCT A-E and E-B showed that most VAE-NT eyes were topographically similar to normal eyes and did not warrant a separate classification based on topography alone. For identifying FFKC eyes, OCT A-E and E-B combined performed significantly better than Scheimpflug (P = .006). For KC eyes, both Scheimpflug and OCT performed equally (P = 1.0). Thus, OCT Topography of Bowman's layer significantly improved the detection of FFKC eyes.
Identifiants
pubmed: 31152630
doi: 10.1002/jbio.201900126
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e201900126Subventions
Organisme : Indo-German Science and Technology Center
ID : SIBAC
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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