The role of lipids in aging-related metabolic changes.
Aging
Mass spectrometry
Odd chain fatty acids
Oxidized lipids
Polyunsaturated fatty acids
Vinyl-Ether lipids
Journal
Chemistry and physics of lipids
ISSN: 1873-2941
Titre abrégé: Chem Phys Lipids
Pays: Ireland
ID NLM: 0067206
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
19
02
2019
revised:
22
05
2019
accepted:
28
05
2019
pubmed:
4
6
2019
medline:
1
4
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
Fat is historically associated with poor health and obesity. However, the continuous use of lipidomics and genetic studies in model organisms revealed that specific lipid profiles and signals might delay aging. In order to identify and quantify the lipid species, researchers are taking advantage of the recent developments in the area of lipidomics that is mainly done by mass spectrometry and further techniques, such as NMR spectroscopy and chromatographic separations. This review will emphasize the role of lipid composition and metabolism during aging. We review the molecular and physiological changes during the progression of aging with a special focus on the role of lipids. Interventions to modulate life span in a variety of organisms such caloric restriction, show a significant extension of their maximum life-span and a decrease in the onset of age-related diseases. In particular, the influence of dietary restriction in lipid metabolism will be a major point of this review.
Identifiants
pubmed: 31152691
pii: S0009-3084(19)30047-7
doi: 10.1016/j.chemphyslip.2019.05.005
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-69Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.