Predicting pharmacokinetic behaviour of drug release from drug-eluting embolization beads using in vitro elution methods.
Animals
Chemoembolization, Therapeutic
/ methods
Doxorubicin
/ pharmacokinetics
Drug Delivery Systems
/ methods
Drug Liberation
/ physiology
In Vitro Techniques
Irinotecan
/ pharmacokinetics
Liver
/ drug effects
Liver Neoplasms
/ drug therapy
Piperidines
/ pharmacokinetics
Quinazolines
/ pharmacokinetics
Swine
Chemoembolisation
Drug delivery
Drug-eluting beads
IVIVC
Vandetanib
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
01 Aug 2019
01 Aug 2019
Historique:
received:
19
10
2018
revised:
03
05
2019
accepted:
27
05
2019
pubmed:
4
6
2019
medline:
7
1
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
Drug-eluting Embolic Bead - Transarterial Chemoembolisation (DEB-TACE) is a minimally invasive embolising treatment for liver tumours that allows local release of chemotherapeutic drugs via ion exchange, following delivery into hepatic arterial vasculature. Thus far, no single in vitro model has been able to accurately predict the complete kinetics of drug release from DEB, due to heterogeneity of rate-controlling mechanisms throughout the process of DEB delivery. In this study, we describe two in vitro models capable of distinguishing between early phase and late phase drug release by mimicking in vivo features of each phase. First, a vascular flow system (VFS) was used to simulate the early phase by delivering DEB into a silicon vascular cast under high pulsatile flow. This yielded a burst release profile of drugs from DEB which related to the dose adjusted C
Identifiants
pubmed: 31152772
pii: S0928-0987(19)30198-8
doi: 10.1016/j.ejps.2019.05.021
pii:
doi:
Substances chimiques
Piperidines
0
Quinazolines
0
Irinotecan
7673326042
Doxorubicin
80168379AG
vandetanib
YO460OQ37K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104943Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.