Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus).
Cavia porcellus
bioavailability
guinea pig
meloxicam
nonsteroidal anti-inflammatory drug
pharmacokinetics
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
06
04
2018
revised:
11
11
2018
accepted:
29
11
2018
pubmed:
4
6
2019
medline:
21
11
2019
entrez:
3
6
2019
Statut:
ppublish
Résumé
To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. Prospective crossover study. A group of six healthy male Dunkin Hartley guinea pigs. A single dose of meloxicam (1.5 mg kg Meloxicam in guinea pigs exhibited a moderate absorption rate after oral dosing (time to maximal plasma concentration 3.7 ± 1.7 hours) and maximal plasma concentration was 0.92 ± 0.30 μg mL This study reported the pharmacokinetics of meloxicam in guinea pigs. Studies concerning efficacy and safety are the next step towards a rational use of this drug in guinea pigs.
Identifiants
pubmed: 31153785
pii: S1467-2987(19)30055-8
doi: 10.1016/j.vaa.2018.11.011
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Meloxicam
VG2QF83CGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
548-555Informations de copyright
Copyright © 2019 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.