Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.

Aged Case-Control Studies Female Humans Male Middle Aged Pulmonary Disease, Chronic Obstructive / complications Smoking / epidemiology
COPD COPDGene chronic bronchitis comorbidities epidemiology sex

Journal

Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335

Informations de publication

Date de publication:
08 2019
Historique:
received: 16 12 2018
revised: 08 04 2019
accepted: 28 04 2019
pubmed: 4 6 2019
medline: 18 4 2020
entrez: 3 6 2019
Statut: ppublish

Résumé

The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and biomarker profiling. The objective of this review was to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, sex, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma/COPD overlap.

Identifiants

DOI: 10.1016/j.chest.2019.04.135 PMID: 31154041 PMC: PMC7198872
pubmed: 31154041
pii: S0012-3692(19)31128-6
doi: 10.1016/j.chest.2019.04.135
pmc: PMC7198872
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT00608764']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

228-238

Subventions

Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL123940
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL123594
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL133438
Pays : United States

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

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Auteurs

Diego J Maselli (DJ)

Division of Pulmonary Diseases and Critical Care, UT Health San Antonio, and South Texas Veterans Health System, San Antonio, TX.

Surya P Bhatt (SP)

Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.

Antonio Anzueto (A)

Division of Pulmonary Diseases and Critical Care, UT Health San Antonio, and South Texas Veterans Health System, San Antonio, TX.

Russell P Bowler (RP)

Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO.

Dawn L DeMeo (DL)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Alejandro A Diaz (AA)

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Mark T Dransfield (MT)

Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.

Ashraf Fawzy (A)

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Marilyn G Foreman (MG)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Morehouse School of Medicine, Atlanta, GA.

Nicola A Hanania (NA)

Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX.

Craig P Hersh (CP)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Victor Kim (V)

Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PA.

Gregory L Kinney (GL)

Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.

Nirupama Putcha (N)

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Emily S Wan (ES)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; VA Boston Healthcare System, Jamaica Plain, MA.

J Michael Wells (JM)

Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.

Gloria E Westney (GE)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Morehouse School of Medicine, Atlanta, GA.

Kendra A Young (KA)

Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.

Edwin K Silverman (EK)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

MeiLan K Han (MK)

Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI.

Barry J Make (BJ)

Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO. Electronic address: makeb@NJHealth.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Clinical Epidemiology of COPD: Insights From...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Clinical Epidemiology of COPD: Insights From...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical Epidemiology of COPD: Insights From...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Clinical Epidemiology of COPD: Insights From...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › Clinical Epidemiology of COPD: Insights From...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Clinical Epidemiology of COPD: Insights From...