Virus like particles of GII.4 norovirus bind Toll Like Receptors 2 and 5.
Immune response
Norovirus
TLR
VLP
Journal
Immunology letters
ISSN: 1879-0542
Titre abrégé: Immunol Lett
Pays: Netherlands
ID NLM: 7910006
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
31
03
2019
revised:
12
05
2019
accepted:
29
05
2019
pubmed:
4
6
2019
medline:
1
5
2020
entrez:
3
6
2019
Statut:
ppublish
Résumé
Norovirus (NoV) is now recognized as a major cause of gastroenteritis outbreaks, worldwide. Norovirus replication mechanisms are still poorly understood, mainly because a reliable cell culture system is still lacking. The present study aims at understanding some aspects of the immune response against norovirus, and particularly the capacity of virus like particles (VLPs) from an Italian strain, belonging to the GII.4 genotype predominating worldwide, to interact with target cells via Toll Like Receptors (TLRs). The capacity of GII.4 NoV VLPs to interact and cause the activation of TLR2, 4 and 5 was studied in recombinant HEK cells. The results obtained show the ability of GII.4 NoV VLPs to induce activation of TLR2 and 5. The results on TLRs activation confirm that GII.4 NoV VLPs interact with TLR2 and 5, that may represent putative receptors and play a role in NoV infection of intestinal cells.
Identifiants
pubmed: 31154053
pii: S0165-2478(19)30160-9
doi: 10.1016/j.imlet.2019.05.016
pii:
doi:
Substances chimiques
TLR2 protein, human
0
TLR5 protein, human
0
Toll-Like Receptor 2
0
Toll-Like Receptor 5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-44Informations de copyright
Copyright © 2019. Published by Elsevier B.V.