Retinal degeneration rat model: A study on the structural and functional changes in the retina following injection of sodium iodate.
Electroretinography
Photoreceptors
Retinal degeneration
Retinal pigment epithelium
Sodium iodate
Journal
Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Titre abrégé: J Photochem Photobiol B
Pays: Switzerland
ID NLM: 8804966
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
26
02
2019
revised:
12
05
2019
accepted:
21
05
2019
pubmed:
4
6
2019
medline:
21
6
2019
entrez:
3
6
2019
Statut:
ppublish
Résumé
Retinal disorders account for a large proportion of ocular disorders that can lead to visual impairment or blindness, and yet our limited knowledge in the pathogenesis and choice of appropriate animal models for new treatment modalities may contribute to ineffective therapies. Although genetic in vivo models are favored, the variable expressivity and penetrance of these heterogeneous disorders can cause difficulties in assessing potential treatments against retinal degeneration. Hence, an attractive alternative is to develop a chemically-induced model that is both cost-friendly and standardizable. Sodium iodate is an oxidative chemical that is used to simulate late stage retinitis pigmentosa and age-related macular degeneration. In this study, retinal degeneration was induced through systemic administration of sodium iodate (NaIO
Identifiants
pubmed: 31154277
pii: S1011-1344(19)30255-6
doi: 10.1016/j.jphotobiol.2019.111514
pii:
doi:
Substances chimiques
Iodates
0
sodium iodate
U558PCS5Z9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111514Informations de copyright
Copyright © 2019. Published by Elsevier B.V.