One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi.

Antifungal Agents / therapeutic use Fluconazole Flucytosine Humans Malawi / epidemiology Meningitis, Cryptococcal / drug therapy
HIV Malawi cryptococcal meningitis long-term follow-up treatment

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
16 01 2020
Historique:
received: 11 03 2019
accepted: 30 05 2019
pubmed: 4 6 2019
medline: 7 1 2021
entrez: 4 6 2019
Statut: ppublish

Résumé

In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).

Identifiants

DOI: 10.1093/cid/ciz454 PMID: 31155650 PMC: PMC7105249
pubmed: 31155650
pii: 5510197
doi: 10.1093/cid/ciz454
pmc: PMC7105249
doi:

Substances chimiques

Antifungal Agents 0
Fluconazole 8VZV102JFY
Flucytosine D83282DT06

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

521-524

Subventions

Organisme : FIC NIH HHS
ID : D43 TW010060
Pays : United States
Organisme : Medical Research Council
ID : G1100814
Pays : United Kingdom
Organisme : Medical Research Council
ID : 100504
Pays : United Kingdom

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

Références

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pubmed: 18990067
Clin Infect Dis. 2014 Mar;58(5):736-45
pubmed: 24319084
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pubmed: 23242412
Clin Infect Dis. 2010 Feb 1;50(3):291-322
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pubmed: 28483415
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Clin Infect Dis. 2010 Feb 1;50(3):338-44
pubmed: 20038244

Auteurs

Cecilia Kanyama (C)

University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.

Síle F Molloy (SF)

Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.

Adrienne K Chan (AK)

Dignitas International, Zomba Central Hospital, Malawi.
Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada.

Duncan Lupiya (D)

Dignitas International, Zomba Central Hospital, Malawi.

Chimwemwe Chawinga (C)

University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.

Jack Adams (J)

Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.

Philip Bright (P)

Dignitas International, Zomba Central Hospital, Malawi.
Clinical Immunology Department, North Bristol National Health Service Trust, United Kingdom.

David G Lalloo (DG)

Liverpool School of Tropical Medicine, United Kingdom.

Robert S Heyderman (RS)

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre.
Department of Medicine, College of Medicine, University of Malawi, Blantyre.
University College London, United Kingdom.

Olivier Lortholary (O)

Institut Pasteur, Molecular Mycology Unit, National Reference Center for Invasive Mycoses & Antifungals, Centre National de la Recherche Scientifique, Paris.
Paris Descartes University, Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Institut Hospitalo-Universitaire Imagine, Assistance Publique - Hôpitaux de Paris, France.

Shabbar Jaffar (S)

Liverpool School of Tropical Medicine, United Kingdom.

Angela Loyse (A)

Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.

Joep J van Oosterhout (JJ)

Dignitas International, Zomba Central Hospital, Malawi.
Department of Medicine, College of Medicine, University of Malawi, Blantyre.

Mina C Hosseinipour (MC)

University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.
Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill.

Thomas S Harrison (TS)

Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › One-year Mortality Outcomes From the Advancing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Fluconazole › One-year Mortality Outcomes From the Advancing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Cytosine › Flucytosine › One-year Mortality Outcomes From the Advancing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › One-year Mortality Outcomes From the Advancing...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique australe › Malawi › One-year Mortality Outcomes From the Advancing...
questionsmedicales.fr › Maladies du système nerveux › Méningite › Méningite fongique › Méningite cryptococcique › One-year Mortality Outcomes From the Advancing...