Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR.
DMFO
HuR
fasting
glycyrrhetinic acid
licorice
organoid
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
02
2019
accepted:
29
04
2019
entrez:
4
6
2019
pubmed:
4
6
2019
medline:
4
6
2019
Statut:
epublish
Résumé
Glycyrrhetinic acid (GA) is one of the main components of the traditional Chinese medicine of licorice, which can coordinate and promote the effects of other medicines in the traditional prescription. We found that GA could promote the proliferation, decrease the apoptotic rate, and attenuate DFMO-elicited growth arrest and delay in restitution after wounding in IEC-6 cells via HuR. GA failed to promote proliferation and to suppress apoptosis after silencing HuR by siRNA in IEC-6 cells. Furthermore, with the model of small intestinal organoids developed from intestinal crypt stem cells, we found that GA could increase HuR and its downstream ki67 levels to promote intestinal organoid development. In the
Identifiants
pubmed: 31156441
doi: 10.3389/fphar.2019.00535
pmc: PMC6531911
doi:
Types de publication
Journal Article
Langues
eng
Pagination
535Références
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