Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin.
anorexia
hyperactivity
leptin
metreleptin treatment
physical activity
starvation
Journal
Frontiers in psychology
ISSN: 1664-1078
Titre abrégé: Front Psychol
Pays: Switzerland
ID NLM: 101550902
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
01
2019
accepted:
20
03
2019
entrez:
4
6
2019
pubmed:
4
6
2019
medline:
4
6
2019
Statut:
epublish
Résumé
The core phenotype of anorexia nervosa (AN) comprises the age and stage dependent intertwining of both its primary and secondary (i.e., starvation induced) somatic and mental symptoms. Hypoleptinemia acts as a key trigger for the adaptation to starvation by affecting diverse brain regions including the reward system and by induction of alterations of the hypothalamus-pituitary-"target-organ" axes, e.g., resulting in amenorrhea as a characteristic symptom of AN. Particularly, the rat model
Identifiants
pubmed: 31156489
doi: 10.3389/fpsyg.2019.00769
pmc: PMC6533856
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
769Références
J Clin Endocrinol Metab. 1999 Mar;84(3):883-94
pubmed: 10084566
Mol Psychiatry. 1999 Jan;4(1):71-5
pubmed: 10089013
J Psychiatr Res. 1999 Mar-Apr;33(2):139-52
pubmed: 10221746
Intern Med. 1999 Feb;38(2):213-5
pubmed: 10225691
Horm Metab Res. 1999 Apr;31(4):274-7
pubmed: 10333084
J Nerv Ment Dis. 1999 Jun;187(6):336-42
pubmed: 10379720
Neuropsychopharmacology. 1999 Oct;21(4):503-6
pubmed: 10481833
N Engl J Med. 1999 Sep 16;341(12):879-84
pubmed: 10486419
J Biol Chem. 1999 Oct 15;274(42):30059-65
pubmed: 10514492
JAMA. 1999 Oct 27;282(16):1568-75
pubmed: 10546697
Science. 2000 Jan 7;287(5450):125-8
pubmed: 10615045
Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1158-65
pubmed: 10827020
Annu Rev Physiol. 2000;62:413-37
pubmed: 10845097
Trends Endocrinol Metab. 2000 Oct;11(8):327-32
pubmed: 10996528
Regul Pept. 2000 Aug 25;92(1-3):37-43
pubmed: 11024563
Mol Psychiatry. 2000 Sep;5(5):476-81
pubmed: 11032380
J Nutr. 2000 Dec;130(12):3127S-3131S
pubmed: 11110887
Neuroendocrinology. 2000 Dec;72(6):341-9
pubmed: 11146417
Eat Weight Disord. 2001 Mar;6(1):49-52
pubmed: 11300546
J Pediatr Endocrinol Metab. 2001 May;14(5):459-80
pubmed: 11393567
J Clin Endocrinol Metab. 2001 Jul;86(7):2982-8
pubmed: 11443155
J Child Psychol Psychiatry. 2001 Jul;42(5):613-22
pubmed: 11464966
J Clin Endocrinol Metab. 2001 Oct;86(10):4753-8
pubmed: 11600536
Eur J Endocrinol. 2001 Nov;145(5):669-73
pubmed: 11720888
J Invest Dermatol. 2001 Dec;117(6):1349-56
pubmed: 11886494
Compr Psychiatry. 2002 May-Jun;43(3):189-94
pubmed: 11994836
Diabetes. 2002 Jul;51(7):2105-12
pubmed: 12086939
J Clin Invest. 2002 Oct;110(8):1093-103
pubmed: 12393845
Int J Obes Relat Metab Disord. 2002 Nov;26(11):1407-33
pubmed: 12439643
Brain Res. 2003 Feb 21;964(1):107-15
pubmed: 12573518
Dtsch Med Wochenschr. 2003 Feb 28;128(9):447-52
pubmed: 12612858
Physiol Behav. 2003 Jun;79(1):25-37
pubmed: 12818707
Pharm Res. 2003 Aug;20(8):1156-62
pubmed: 12948012
J Comp Physiol Psychol. 1954 Oct;47(5):362-3
pubmed: 13221681
Psychosom Med. 1962 Mar-Apr;24:187-94
pubmed: 13873828
Circulation. 1963 Sep;28:381-95
pubmed: 14059458
Recent Prog Horm Res. 2004;59:305-31
pubmed: 14749508
Eat Behav. 2001 Summer;2(2):151-68
pubmed: 15001043
Psychol Med. 2004 May;34(4):671-9
pubmed: 15099421
Nat Med. 2004 Jun;10(6):563-9
pubmed: 15170194
J Neural Transm (Vienna). 2004 Jul;111(7):827-40
pubmed: 15206001
Int J Eat Disord. 2004 Sep;36(2):163-71
pubmed: 15282686
N Engl J Med. 2004 Sep 2;351(10):987-97
pubmed: 15342807
J Biol Chem. 2005 Mar 18;280(11):10034-9
pubmed: 15644325
Reprod Toxicol. 2005 Sep-Oct;20(3):345-52
pubmed: 15893910
Physiol Behav. 2005 Jun 2;85(2):151-7
pubmed: 15924912
Int J Eat Disord. 2005 Jul;38(1):24-9
pubmed: 15991218
Biol Psychiatry. 2005 Dec 1;58(11):908-12
pubmed: 15992780
Am J Clin Nutr. 2005 Jul;82(1 Suppl):222S-225S
pubmed: 16002825
Biol Psychiatry. 2005 Jul 15;58(2):165-71
pubmed: 16038687
Int J Eat Disord. 2006 Mar;39(2):147-53
pubmed: 16231344
Biol Psychiatry. 2006 Aug 1;60(3):311-3
pubmed: 16376860
Nat Med. 2006 May;12(5):534-40
pubmed: 16604086
Psychiatry Res. 2006 Jun 15;142(2-3):253-5
pubmed: 16626809
Int J Eat Disord. 2006 Sep;39(6):454-61
pubmed: 16637047
Neuron. 2006 Sep 21;51(6):801-10
pubmed: 16982424
Mol Psychiatry. 2007 Jan;12(1):23-35
pubmed: 17060920
Am J Clin Nutr. 2007 Apr;85(4):967-71
pubmed: 17413094
Peptides. 2007 Jun;28(6):1317-30
pubmed: 17540480
Eur Eat Disord Rev. 2007 Mar;15(2):112-8
pubmed: 17676679
Eur Eat Disord Rev. 2007 Nov;15(6):425-9
pubmed: 17680592
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18276-9
pubmed: 17986612
Eur Eat Disord Rev. 2008 Mar;16(2):100-8
pubmed: 18000964
Psychol Med. 2008 Oct;38(10):1443-53
pubmed: 18070371
J Health Psychol. 2008 May;13(4):495-502
pubmed: 18420757
Physiol Behav. 2008 Aug 6;94(5):689-95
pubmed: 18495181
Compr Psychiatry. 2008 Jul-Aug;49(4):346-52
pubmed: 18555054
J Clin Invest. 2008 Jul;118(7):2583-91
pubmed: 18568078
Front Neuroendocrinol. 2008 Oct;29(4):445-62
pubmed: 18602416
Curr Pharm Des. 2008;14(16):1615-9
pubmed: 18673203
PLoS One. 2008 Aug 29;3(8):e3098
pubmed: 18769731
Eat Behav. 2008 Dec;9(4):423-9
pubmed: 18928905
Eur Neuropsychopharmacol. 2009 Mar;19(3):153-60
pubmed: 18977121
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):658-62
pubmed: 19296912
Obesity (Silver Spring). 2009 Sep;17(9):1736-43
pubmed: 19521351
Nat Rev Neurosci. 2009 Aug;10(8):573-84
pubmed: 19603056
Neurosci Biobehav Rev. 2010 Jan;34(1):73-9
pubmed: 19619579
J Investig Med. 2009 Oct;57(7):784-8
pubmed: 19730134
J Neurosci. 2009 Sep 16;29(37):11582-93
pubmed: 19759305
Trends Endocrinol Metab. 2010 Feb;21(2):68-74
pubmed: 19818643
Phys Sportsmed. 2009 Oct;37(3):20-8
pubmed: 20048525
J Clin Invest. 2010 Mar;120(3):720-34
pubmed: 20160350
J Neurosci. 2010 Apr 21;30(16):5713-23
pubmed: 20410123
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14875-80
pubmed: 20679202
Compr Psychiatry. 2010 Nov-Dec;51(6):566-71
pubmed: 20965301
Curr Top Behav Neurosci. 2011;6:95-110
pubmed: 21243472
J Neural Transm (Vienna). 2011 Apr;118(4):571-8
pubmed: 21258826
Obes Rev. 2011 May;12(5):e315-23
pubmed: 21410864
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6585-90
pubmed: 21464293
Mol Psychiatry. 2011 Oct;16(10):1024-38
pubmed: 21483433
J Clin Endocrinol Metab. 2011 Aug;96(8):E1283-7
pubmed: 21593110
Diabetes. 2011 Jun;60(6):1647-56
pubmed: 21617185
Arch Gen Psychiatry. 2011 Jul;68(7):724-31
pubmed: 21727255
Metabolism. 2011 Sep;60(9):1211-21
pubmed: 21741057
Eur J Neurosci. 2011 Nov;34(9):1485-91
pubmed: 22034979
Endocr Pract. 2011 Nov-Dec;17(6):922-32
pubmed: 22068254
Int J Eat Disord. 2011 Dec;44(8):665-78
pubmed: 22072403
Eur Child Adolesc Psychiatry. 2012 Feb;21(2):63-6
pubmed: 22290117
Horm Res Paediatr. 2012;77(2):127-33
pubmed: 22343341
Cell Metab. 2012 Mar 7;15(3):292-7
pubmed: 22405067
Mol Cell Biol. 2012 May;32(10):1867-78
pubmed: 22431513
Neuropsychopharmacology. 2012 Aug;37(9):2031-46
pubmed: 22549118
PLoS One. 2012;7(7):e41851
pubmed: 22848634
Int J Neuropsychopharmacol. 2013 May;16(4):857-67
pubmed: 22932068
Br J Nutr. 2013 Jun 28;109(12):2175-81
pubmed: 23116966
EMBO Rep. 2012 Dec;13(12):1079-86
pubmed: 23146889
Prog Mol Biol Transl Sci. 2013;114:147-91
pubmed: 23317785
Ann Hematol. 2013 May;92(5):605-13
pubmed: 23392575
PLoS One. 2013;8(2):e56275
pubmed: 23460796
Med Sci Sports Exerc. 2013 Sep;45(9):1643-8
pubmed: 23475165
Arch Gen Psychiatry. 1990 Jun;47(6):548-56
pubmed: 2350207
Soc Cogn Affect Neurosci. 2014 Jul;9(7):917-23
pubmed: 23677490
Drugs. 2013 Jun;73(9):989-97
pubmed: 23740412
PLoS One. 2013 Jun 14;8(6):e65893
pubmed: 23799059
Biol Psychol. 2013 Dec;94(3):575-81
pubmed: 24161801
PLoS One. 2013 Oct 21;8(10):e78251
pubmed: 24205172
Int J Eat Disord. 2015 Jan;48(1):42-5
pubmed: 24687461
Cell Metab. 2014 Apr 1;19(4):682-93
pubmed: 24703699
Eat Weight Disord. 2014 Dec;19(4):525-30
pubmed: 24821487
J Eat Disord. 2013 May 02;1:16
pubmed: 24999397
J Endocrinol. 2014 Oct;223(1):T9-23
pubmed: 25063754
J Clin Psychiatry. 2015 Jan;76(1):19-24
pubmed: 25098834
Behav Res Ther. 2014 Nov;62:47-59
pubmed: 25151600
Metabolism. 2015 Jan;64(1):146-56
pubmed: 25156686
Int J Eat Disord. 2015 Jan;48(1):46-54
pubmed: 25196139
Neurosci Biobehav Rev. 2014 Nov;47:295-306
pubmed: 25205078
J Endocrinol. 2014 Oct;223(1):T63-70
pubmed: 25232148
Handb Clin Neurol. 2014;124:373-86
pubmed: 25248600
Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):635-47
pubmed: 25256760
Front Endocrinol (Lausanne). 2014 Oct 13;5:167
pubmed: 25352831
Obesity (Silver Spring). 2015 Jan;23(1):7-15
pubmed: 25469998
Obesity (Silver Spring). 2015 Jan;23(1):2-3
pubmed: 25504330
Neuroscience. 2015 Apr 2;290:445-53
pubmed: 25637491
Neurosci Biobehav Rev. 2015 May;52:131-52
pubmed: 25735957
Eur Eat Disord Rev. 2015 Sep;23(5):333-44
pubmed: 26087044
Int J Obes (Lond). 2015 Dec;39(12):1742-9
pubmed: 26183405
Cell Metab. 2015 Oct 6;22(4):741-9
pubmed: 26341832
Int J Neuropsychopharmacol. 2015 Oct 05;19(2):null
pubmed: 26438799
Nat Neurosci. 2015 Nov;18(11):1571-3
pubmed: 26457555
Expert Rev Clin Pharmacol. 2016;9(1):59-68
pubmed: 26465174
Obes Rev. 2016 Jan;17(1):81-93
pubmed: 26490059
Brain Res. 2016 Aug 15;1645:68-70
pubmed: 26731335
Neural Plast. 2016;2016:8528934
pubmed: 26881138
Channels (Austin). 2016 Jul 3;10(4):282-96
pubmed: 27018500
Nutr Rev. 2016 May;74(5):301-11
pubmed: 27052638
Eur J Clin Nutr. 2016 Nov;70(11):1305-1308
pubmed: 27436150
Cell Metab. 2016 Aug 9;24(2):194-5
pubmed: 27452145
N Engl J Med. 2016 Jul 21;375(3):240-6
pubmed: 27468060
J Diabetes Metab. 2016 Mar;7(3):null
pubmed: 27642538
CNS Neurol Disord Drug Targets. 2016;15(9):1118-1128
pubmed: 27658512
Transl Psychiatry. 2016 Nov 1;6(11):e932
pubmed: 27801897
Harv Rev Psychiatry. 2016 Nov/Dec;24(6):416-436
pubmed: 27824637
Int J Eat Disord. 2017 Apr;50(4):378-388
pubmed: 28093835
Neuropsychopharmacology. 2017 Nov;42(12):2292-2300
pubmed: 28322236
Eur Eat Disord Rev. 2017 May;25(3):195-204
pubmed: 28402067
J Neuroendocrinol. 2017 Oct;29(10):
pubmed: 28475260
Int J Adolesc Med Health. 2017 Aug 29;:null
pubmed: 28850546
Eat Weight Disord. 2018 Dec;23(6):897-902
pubmed: 28871553
Eat Weight Disord. 2018 Oct;23(5):581-586
pubmed: 28884261
Biol Psychiatry. 2018 Feb 1;83(3):224-234
pubmed: 28967386
Mol Metab. 2017 Oct;6(10):1321-1329
pubmed: 29031731
Nutrients. 2017 Nov 03;9(11):
pubmed: 29099750
Metabolism. 2018 Mar;80:91-104
pubmed: 29107598
J Clin Psychiatry. 2018 Jan/Feb;79(1):null
pubmed: 29325236
J Eat Disord. 2018 Mar 2;6:4
pubmed: 29507720
Endocrine. 2018 Jun;60(3):479-489
pubmed: 29644599
Nat Med. 2018 May;24(5):551-555
pubmed: 29736023
Front Neurosci. 2018 Apr 24;12:271
pubmed: 29740277
Peptides. 2018 Aug;106:49-58
pubmed: 29953915
JAMA Psychiatry. 2018 Oct 1;75(10):1071-1080
pubmed: 30027213
JAMA Psychiatry. 2018 Oct 1;75(10):993-994
pubmed: 30027294
Adv Exp Med Biol. 2018;1090:183-198
pubmed: 30390291
Front Psychol. 2018 Nov 23;9:2303
pubmed: 30532724
Eur J Clin Nutr. 1988 Nov;42(11):929-37
pubmed: 3074921
Gut. 1968 Aug;9(4):370-2
pubmed: 4877900
J Comp Physiol Psychol. 1967 Dec;64(3):414-21
pubmed: 6082873
Compr Psychiatry. 1978 Sep-Oct;19(5):433-40
pubmed: 679677
Br Med J. 1980 Dec 20-27;281(6256):1669-75
pubmed: 7004564
Lancet. 1995 Dec 16;346(8990):1624-5
pubmed: 7500762
Science. 1995 Jul 28;269(5223):543-6
pubmed: 7624777
Am J Psychiatry. 1995 Jul;152(7):1073-4
pubmed: 7793446
Psychol Med. 1994 Nov;24(4):957-67
pubmed: 7892363
Nature. 1994 Dec 1;372(6505):425-32
pubmed: 7984236
Nutr Rev. 1994 Mar;52(3):84-94
pubmed: 8015751
Cell. 1995 Dec 29;83(7):1263-71
pubmed: 8548812
Nat Med. 1996 Jan;2(1):21-2
pubmed: 8564826
Nat Genet. 1996 Mar;12(3):318-20
pubmed: 8589726
Nat Med. 1996 May;2(5):585-9
pubmed: 8616721
Diabetes. 1996 Jul;45(7):984-7
pubmed: 8666153
FEBS Lett. 1996 Jun 3;387(2-3):113-6
pubmed: 8674530
Peptides. 1996;17(2):305-11
pubmed: 8801538
J Clin Invest. 1996 Sep 15;98(6):1277-82
pubmed: 8823291
Diabetes. 1996 Oct;45(10):1435-8
pubmed: 8826983
J Clin Endocrinol Metab. 1996 Nov;81(11):3861-3
pubmed: 8923829
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14564-8
pubmed: 8962092
Can J Psychiatry. 1997 Mar;42(2):168-75
pubmed: 9067066
Biochem Biophys Res Commun. 1997 Mar 17;232(2):383-7
pubmed: 9125186
Br J Sports Med. 1997 Mar;31(1):70-2
pubmed: 9132218
J Clin Endocrinol Metab. 1997 Jun;82(6):1845-51
pubmed: 9177394
Nature. 1997 Jun 26;387(6636):903-8
pubmed: 9202122
Mol Psychiatry. 1997 Jul;2(4):330-4
pubmed: 9246674
Mol Psychiatry. 1997 Jul;2(4):335-40
pubmed: 9246675
J Clin Invest. 1997 Aug 15;100(4):808-13
pubmed: 9259579
Obes Res. 1997 Sep;5(5):498-502
pubmed: 9385628
Compr Psychiatry. 1997 Nov-Dec;38(6):321-6
pubmed: 9406737
Am J Epidemiol. 1998 Feb 1;147(3):213-6
pubmed: 9482494
Lancet. 1998 Mar 7;351(9104):737-42
pubmed: 9504534
J Clin Endocrinol Metab. 1998 Mar;83(3):791-5
pubmed: 9506729
Horm Metab Res. 1998 May;30(5):272-5
pubmed: 9660088
Anim Behav. 1998 Jul;56(1):11-27
pubmed: 9710457