Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice.
HIV
conserved
live-attenuated vaccines
mycobacteria
rBCG
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
01
2019
accepted:
10
04
2019
entrez:
4
6
2019
pubmed:
4
6
2019
medline:
10
9
2020
Statut:
epublish
Résumé
BCG is currently the only licensed vaccine against tuberculosis (TB) and confers protection against meningitis and miliary tuberculosis in infants, although pulmonary disease protection in adults is inconsistent. Recently, promising HIV-1 immunogens were developed, such as the T-cell immunogens "tHIVconsvX," designed using functionally conserved protein regions across group M strains, with mosaic immunogens to improve HIV-1 variant match and response breadth. In this study, we constructed an integrative
Identifiants
pubmed: 31156614
doi: 10.3389/fimmu.2019.00923
pmc: PMC6530512
doi:
Substances chimiques
AIDS Vaccines
0
Antigens, Viral
0
BCG Vaccine
0
Vaccines, Live, Unattenuated
0
Vaccines, Synthetic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
923Subventions
Organisme : Medical Research Council
ID : G1001757
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N023668/1
Pays : United Kingdom
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