Immune Control by TRAF6-Mediated Pathways of Epithelial Cells in the EIME (Epithelial Immune Microenvironment).
Animals
Biomarkers
Blood Cells
/ immunology
Carrier Proteins
Disease Susceptibility
Epithelial Cells
/ metabolism
Epithelium
/ immunology
Humans
Immune System
/ immunology
Immunomodulation
Interleukin-17
/ metabolism
Intracellular Signaling Peptides and Proteins
/ genetics
Phagocytes
/ immunology
Protein Binding
Signal Transduction
Ubiquitin-Protein Ligases
/ metabolism
Ubiquitination
EIME
IL-17
MAPK
NF-kappaB
TRAF6
keratinocyte
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
03
2019
accepted:
01
05
2019
entrez:
4
6
2019
pubmed:
4
6
2019
medline:
10
9
2020
Statut:
epublish
Résumé
In the protective responses of epithelial tissues, not only immune cells but also non-immune cells directly respond to external agents. Epithelial cells can be involved in the organization of immune responses through two phases. First, the exogenous harmful agents trigger the primary responses of the epithelial cells leading to various types of immune cell activation. Second, cytokines produced by the immune cells that are activated directly by the external agents and indirectly by the epithelial cell products elicit the secondary responses giving rise to further propagation of immune responses. TRAF6 is a ubiquitin E3 ligase, which intermediates between various types of receptors for exogenous agents or endogenous mediators and activation of subsequent transcriptional responses via NF-kappaB and MAPK pathways. TRAF6 ubiquitously participates in many protective responses in immune and non-immune cells. Particularly, epithelial TRAF6 has an essential role in the primary and secondary responses via driving type 17 response in psoriatic inflammation of the skin. Consistently, many psoriasis susceptibility genes encode the TRAF6 signaling players, such as ACT1 (
Identifiants
pubmed: 31156649
doi: 10.3389/fimmu.2019.01107
pmc: PMC6532024
doi:
Substances chimiques
Biomarkers
0
Carrier Proteins
0
Interleukin-17
0
Intracellular Signaling Peptides and Proteins
0
Tifab protein, human
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1107Références
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