Noninvasive imaging of the tree shrew eye: Wavefront analysis and retinal imaging with correlative histology.
Aberrometry
Animals
Cell Count
Corneal Wavefront Aberration
/ physiopathology
Microscopy, Electron, Transmission
Ophthalmoscopy
Optical Imaging
Refraction, Ocular
/ physiology
Refractive Errors
/ physiopathology
Retina
/ diagnostic imaging
Retinal Cone Photoreceptor Cells
/ cytology
Tomography, Optical Coherence
/ methods
Tupaia
Adaptive optics
Cone photoreceptors
Megamitochondria
Optical coherence tomography
Tree shrew
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
07
04
2019
revised:
21
05
2019
accepted:
28
05
2019
pubmed:
4
6
2019
medline:
15
2
2020
entrez:
4
6
2019
Statut:
ppublish
Résumé
Tree shrews are small mammals with excellent vision and are closely related to primates. They have been used extensively as a model for studying refractive development, myopia, and central visual processing and are becoming an important model for vision research. Their cone dominant retina (∼95% cones) provides a potential avenue to create new damage/disease models of human macular pathology and to monitor progression or treatment response. To continue the development of the tree shrew as an animal model, we provide here the first measurements of higher order aberrations along with adaptive optics scanning light ophthalmoscopy (AOSLO) images of the photoreceptor mosaic in the tree shrew retina. To compare intra-animal in vivo and ex vivo cone density measurements, the AOSLO images were matched to whole-mount immunofluorescence microscopy. Analysis of the tree shrew wavefront indicated that the optics are well-matched to the sampling of the cone mosaic and is consistent with the suggestion that juvenile tree shrews are nearly emmetropic (slightly hyperopic). Compared with in vivo measurements, consistently higher cone density was measured ex vivo, likely due to tissue shrinkage during histological processing. Tree shrews also possess massive mitochondria ("megamitochondria") in their cone inner segments, providing a natural model to assess how mitochondrial size affects in vivo retinal imagery. Intra-animal in vivo and ex vivo axial distance measurements were made in the outer retina with optical coherence tomography (OCT) and transmission electron microscopy (TEM), respectively, to determine the origin of sub-cellular cone reflectivity seen on OCT. These results demonstrate that these megamitochondria create an additional hyper-reflective outer retinal reflective band in OCT images. The ability to use noninvasive retinal imaging in tree shrews supports development of this species as a model of cone disorders.
Identifiants
pubmed: 31158381
pii: S0014-4835(19)30259-3
doi: 10.1016/j.exer.2019.05.023
pmc: PMC6698412
mid: NIHMS1036772
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107683Subventions
Organisme : NEI NIH HHS
ID : P30 EY001931
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY014537
Pays : United States
Organisme : NEI NIH HHS
ID : U01 EY025477
Pays : United States
Organisme : NEI NIH HHS
ID : U24 EY029891
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY003039
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR016511
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY005922
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Références
Vision Res. 1984;24(9):1037-42
pubmed: 6506467
J Pathol. 2016 Jan;238(2):300-10
pubmed: 26387748
J Cell Physiol. 2018 Feb;233(2):1434-1445
pubmed: 28542832
Anat Embryol (Berl). 1983;167(1):95-102
pubmed: 6881545
Vision Res. 1985;25(9):1207-21
pubmed: 4072000
J Biophys Biochem Cytol. 1957 Jan 25;3(1):15-30
pubmed: 13416308
Transl Vis Sci Technol. 2017 Sep 6;6(5):5
pubmed: 28900578
J Opt Soc Am A Opt Image Sci Vis. 2007 Mar;24(3):569-77
pubmed: 17301846
J Opt Soc Am A Opt Image Sci Vis. 2000 Mar;17(3):557-67
pubmed: 10708037
J Vis. 2004 Apr 16;4(4):272-80
pubmed: 15134474
J Comp Neurol. 1992 May 1;319(1):159-71
pubmed: 1375607
PLoS One. 2014 Mar 05;9(3):e90390
pubmed: 24599007
J Comp Neurol. 1987 Jan 1;255(1):18-34
pubmed: 2434534
Hum Mol Genet. 2016 Oct 15;25(20):4376-4388
pubmed: 28172828
Exp Eye Res. 2002 Apr;74(4):435-44
pubmed: 12076087
Annu Rev Vis Sci. 2015 Nov 24;1:125-153
pubmed: 28532376
Biomed Opt Express. 2011 Sep 1;2(9):2577-89
pubmed: 21991550
Exp Eye Res. 2016 Sep;150:90-105
pubmed: 26808487
Retina. 2018 Mar;38(3):445-461
pubmed: 29210936
Opt Express. 2004 May 17;12(10):2156-65
pubmed: 19475051
J Cell Biol. 1966 Mar;28(3):489-504
pubmed: 5960809
Biomed Opt Express. 2011 Feb 28;2(4):717-38
pubmed: 21483598
Transl Vis Sci Technol. 2017 Apr 3;6(2):9
pubmed: 28392976
Curr Biol. 2018 Jun 4;28(11):1818-1824.e2
pubmed: 29804805
J Comp Neurol. 1989 Apr 22;282(4):581-94
pubmed: 2723153
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3109-18
pubmed: 16799057
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1037-1044
pubmed: 28192795
J Biomed Opt. 2002 Jul;7(3):457-63
pubmed: 12175297
Retina. 2011 Sep;31(8):1609-19
pubmed: 21844839
Vision Res. 2004 Mar;44(7):643-53
pubmed: 14751549
Opt Express. 2004 May 31;12(11):2435-47
pubmed: 19475080
Vis Neurosci. 1991 Feb;6(2):95-111
pubmed: 2049333
Sci Rep. 2018 Jan 29;8(1):1813
pubmed: 29379036
Optom Vis Sci. 2003 Sep;80(9):623-31
pubmed: 14502042
J Neurosci. 2005 Oct 19;25(42):9669-79
pubmed: 16237171
Vision Res. 1987;27(1):9-15
pubmed: 3303679
Vis Neurosci. 1998 Jul-Aug;15(4):685-91
pubmed: 9682870
Opt Express. 2010 Nov 22;18(24):24902-16
pubmed: 21164835
Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4687-99
pubmed: 17065475
Vision Res. 2011 Feb 9;51(3):376-85
pubmed: 21156186
Vision Res. 1979;19(11):1273-5
pubmed: 121653
J Vis. 2015;15(9):19
pubmed: 26230981
Neuron. 2013 Feb 6;77(3):516-27
pubmed: 23395377
Vision Res. 1992 May;32(5):833-42
pubmed: 1604852
J Comp Neurol. 1995 Jul 31;358(3):401-13
pubmed: 7560294
Prog Retin Eye Res. 2015 Sep;48:137-59
pubmed: 25936606
Lab Anim Sci. 1994 Jun;44(3):292-4
pubmed: 7933981
Invest Ophthalmol Vis Sci. 2011 Jun 06;52(7):3943-54
pubmed: 21421869
Biomed Opt Express. 2012 Aug 1;3(8):1811-24
pubmed: 22876346
J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1358-63
pubmed: 17429481
Vision Res. 2000;40(4):455-8
pubmed: 10820625
Clin Exp Ophthalmol. 2015 May-Jun;43(4):358-66
pubmed: 24533647
Ophthalmology. 2014 Aug;121(8):1572-8
pubmed: 24755005
Prog Retin Eye Res. 2017 Nov;61:72-97
pubmed: 28668352
Optom Vis Sci. 1997 Jul;74(7):483-8
pubmed: 9293514
Vision Res. 2010 Mar 17;50(6):564-76
pubmed: 20045711
J Opt Soc Am A Opt Image Sci Vis. 2001 Aug;18(8):1793-803
pubmed: 11488483
Vis Neurosci. 2002 Jul-Aug;19(4):395-407
pubmed: 12511073
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15922-7
pubmed: 26668363
Phys Med Biol. 2008 Sep 21;53(18):4995-5009
pubmed: 18711247
Brain Res. 1972 Jul 20;42(2):491-6
pubmed: 5050179
Curr Eye Res. 2011 Mar;36(3):278-84
pubmed: 21275518
Vis Neurosci. 2016;33:e003
pubmed: 26923645
J Refract Surg. 2002 Sep-Oct;18(5):S652-60
pubmed: 12361175
Optom Vis Sci. 2018 Oct;95(10):911-920
pubmed: 30179995
Vision Res. 2001;41(10-11):1291-306
pubmed: 11322974
Vis Neurosci. 1994 May-Jun;11(3):501-17
pubmed: 8038125
J Biomed Opt. 2007 Jan-Feb;12(1):014010
pubmed: 17343485
PLoS One. 2015 Dec 14;10(12):e0144891
pubmed: 26660894
J Cataract Refract Surg. 2006 Dec;32(12):2064-74
pubmed: 17137985
Invest Ophthalmol. 1975 Jun;14(6):457-67
pubmed: 166050
J Comp Neurol. 1984 Dec 10;230(3):337-51
pubmed: 6520238
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):414-23
pubmed: 18708623
Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2538-2547
pubmed: 29847661
Vis Neurosci. 2016 Jan;33:E005
pubmed: 27484961
Vision Res. 1985;25(10):1477-91
pubmed: 4090282
Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):3136-3143
pubmed: 30025140
Vision Res. 1986;26(2):291-8
pubmed: 3716222
eNeuro. 2018 Jul 11;5(4):
pubmed: 30073190
Transl Vis Sci Technol. 2017 Apr 3;6(2):8
pubmed: 28392975
Invest Ophthalmol Vis Sci. 1977 Sep;16(9):815-40
pubmed: 893032
J Opt Soc Am A Opt Image Sci Vis. 1997 Nov;14(11):2873-83
pubmed: 9379245
Nature. 1999 Feb 11;397(6719):520-2
pubmed: 10028967
Brain Res. 1993 Jul 9;616(1-2):344-50
pubmed: 8358626
Invest Ophthalmol Vis Sci. 2014 Jun 06;55(7):4244-51
pubmed: 24906859
Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4559-4568
pubmed: 28877320
Vision Res. 1997 Feb;37(3):267-71
pubmed: 9135860
Nature. 2016 May 5;533(7601):90-4
pubmed: 27120162
Science. 1970 May 1;168(3931):605-6
pubmed: 5436596
Opt Express. 2004 May 31;12(11):2404-22
pubmed: 19475077
Biomed Opt Express. 2011 Jul 1;2(7):1864-76
pubmed: 21750765
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Vision Res. 1985;25(11):1557-67
pubmed: 3832579
Biomed Opt Express. 2016 Nov 03;7(12):4899-4918
pubmed: 28018714
Jpn J Ophthalmol. 2009 May;53(3):249-56
pubmed: 19484444
J Gen Physiol. 2018 Apr 2;150(4):571-590
pubmed: 29500274
Biomed Opt Express. 2012 Jul 1;3(7):1647-61
pubmed: 22808435
Biomed Opt Express. 2016 Apr 27;7(5):2036-50
pubmed: 27231641