A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease.
Absorptiometry, Photon
Adult
Aged
Body Composition
Body Mass Index
Bone Density
/ physiology
Bone and Bones
/ diagnostic imaging
Female
Humans
Kidney Failure, Chronic
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Multimodal Imaging
Muscles
/ diagnostic imaging
Renal Dialysis
Tomography, X-Ray Computed
Young Adult
Bone mineral density
Chronic kidney disease
DXA
MRI
Quantitative computed tomography
Sarcopenia
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
04
04
2016
revised:
16
05
2019
accepted:
16
05
2019
pubmed:
4
6
2019
medline:
5
9
2020
entrez:
4
6
2019
Statut:
ppublish
Résumé
End stage renal disease (ESRD) is associated with sarcopenia and skeletal fragility. The objectives of this cross-sectional study were to (1) characterize body composition, bone mineral density (BMD) and bone structure in hemodialysis patients compared with controls, (2) assess whether DXA areal BMD (aBMD) correlates with peripheral quantitative CT (pQCT) measures of volumetric BMD (vBMD), cortical dimensions and MRI measures of trabecular microarchitecture, and (3) determine the magnitude of bone deficits in ESRD after adjustment for muscle mass. Thirty ESRD participants, ages 25 to 64 years, were compared with 403 controls for DXA and pQCT outcomes and 104 controls for MRI outcomes; results were expressed as race- and sex- specific Z-scores relative to age. DXA appendicular lean mass index (ALMI kg/m
Identifiants
pubmed: 31158505
pii: S8756-3282(19)30197-8
doi: 10.1016/j.bone.2019.05.022
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
271-279Subventions
Organisme : NIDDK NIH HHS
ID : K24 DK076808
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK074105
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK064966
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR068382
Pays : United States
Organisme : NIAMS NIH HHS
ID : R03 AR064577
Pays : United States
Organisme : NIAMS NIH HHS
ID : K25 AR060283
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK060455
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024134
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000003
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.