Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.
Aminophthalazine derivatives
MY5445
Neuropathic pain
PDE-5 inhibitors
Structure activity relationship (SAR) studies
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Sep 2019
01 Sep 2019
Historique:
received:
21
01
2019
revised:
30
04
2019
accepted:
07
05
2019
pubmed:
4
6
2019
medline:
26
7
2019
entrez:
4
6
2019
Statut:
ppublish
Résumé
Neuropathic pain is a chronic pain caused by a lesion or disease affecting the somatosensory nervous system. To date, no specific treatment has been developed to cure this pain. Antidepressants and anticonvulsant drugs are used, but they do not demonstrate universal efficacy, and they often cause detrimental adverse effects. Some studies highlighted the efficacy of sildenafil, a well-known inhibitor of phosphodiesterase 5 (PDE5, (IC
Identifiants
pubmed: 31158744
pii: S0223-5234(19)30435-0
doi: 10.1016/j.ejmech.2019.05.026
pii:
doi:
Substances chimiques
Analgesics
0
Phosphodiesterase 5 Inhibitors
0
Phthalazines
0
MY 5445
F8CSS73B6A
Types de publication
Journal Article
Langues
eng
Pagination
269-290Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.