Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy
Animals
Biocompatible Materials
Biomarkers
Cell- and Tissue-Based Therapy
Cord Blood Stem Cell Transplantation
Disease Models, Animal
Humans
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ cytology
Nerve Growth Factors
/ metabolism
Nerve Regeneration
Regenerative Medicine
Spinal Cord Injuries
/ etiology
Spinal Cord Regeneration
Tissue Scaffolds
Translational Research, Biomedical
mesenchymal stem cells
regenerative medicine
spinal cord injury
translational medicine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 05 2019
31 05 2019
Historique:
received:
17
04
2019
revised:
29
05
2019
accepted:
30
05
2019
entrez:
5
6
2019
pubmed:
5
6
2019
medline:
26
11
2019
Statut:
epublish
Résumé
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns the well-known secondary injury, which is the uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. The use of mesenchymal stem cells (MSCs) represents one of the most important and promising tested strategies. Their appeal, among the other sources and types of stem cells, increased because of their ease of isolation/preservation and their properties. Nevertheless, encouraging promise from preclinical studies was followed by weak and conflicting results in clinical trials. In this review, the therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.
Identifiants
pubmed: 31159345
pii: ijms20112698
doi: 10.3390/ijms20112698
pmc: PMC6600381
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Biomarkers
0
Nerve Growth Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Nat Med. 1999 Dec;5(12):1410-2
pubmed: 10581084
Nature. 2000 Jan 27;403(6768):439-44
pubmed: 10667797
Prog Brain Res. 2000;128:9-21
pubmed: 11105665
Exp Neurol. 2001 Jan;167(1):48-58
pubmed: 11161592
Nature. 2001 Jan 18;409(6818):341-6
pubmed: 11201742
Exp Neurol. 2001 Apr;168(2):283-9
pubmed: 11259116
Tissue Eng. 2001 Apr;7(2):211-28
pubmed: 11304456
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2199-204
pubmed: 11854516
Nature. 2002 Apr 4;416(6880):485-7
pubmed: 11932725
Blood. 2002 May 15;99(10):3838-43
pubmed: 11986244
Nat Immunol. 2002 Jul;3(7):687-94
pubmed: 12068293
Exp Hematol. 2002 Aug;30(8):879-86
pubmed: 12160839
Neuroscience. 2003;118(1):11-7
pubmed: 12676132
Cells Tissues Organs. 2003;174(3):101-9
pubmed: 12835573
J Comp Neurol. 1954 Apr;100(2):297-379
pubmed: 13163236
J Neurotrauma. 1992 Summer;9(2):147-9; discussion 149-50
pubmed: 1404430
Nat Cell Biol. 2003 Nov;5(11):952-4
pubmed: 14593417
Artif Organs. 2004 Jan;28(1):33-9
pubmed: 14720286
J Comp Neurol. 1952 Jun;96(3):414-95
pubmed: 14946260
J Cell Sci. 2004 Mar 1;117(Pt 7):1269-80
pubmed: 14996946
Curr Opin Neurobiol. 2004 Feb;14(1):118-24
pubmed: 15018947
J Neurosci Res. 2004 Jul 15;77(2):174-91
pubmed: 15211585
Exp Neurol. 2005 Feb;191(2):344-60
pubmed: 15649491
Cell Tissue Res. 2005 Feb;319(2):243-53
pubmed: 15654654
J Neurotrauma. 2004 Oct;21(10):1355-70
pubmed: 15672627
Brain Res. 2005 Feb 21;1035(1):73-85
pubmed: 15713279
Stem Cells. 2005 Mar;23(3):392-402
pubmed: 15749934
Int J Hematol. 2005 Feb;81(2):126-30
pubmed: 15765780
J Neurosci. 2005 May 11;25(19):4694-705
pubmed: 15888645
Injury. 2005 Jul;36 Suppl 2:B13-26
pubmed: 15993113
Tissue Eng. 2005 May-Jun;11(5-6):913-22
pubmed: 15998231
Acta Neurochir (Wien). 2005 Sep;147(9):985-92; discussion 992
pubmed: 16010451
J Inflamm (Lond). 2005 Jul 26;2:8
pubmed: 16045800
Blood. 2006 Jan 1;107(1):367-72
pubmed: 16141348
Cytotherapy. 2005;7(4):368-73
pubmed: 16162459
Stem Cells. 2006 Apr;24(4):1054-64
pubmed: 16322639
Exp Neurol. 2006 Mar;198(1):54-64
pubmed: 16336965
Cytotherapy. 2006;8(3):202-9
pubmed: 16793729
Cytotherapy. 2006;8(3):210-4
pubmed: 16793730
Ann Neurol. 2006 Jul;60(1):32-44
pubmed: 16802299
Neurol Res. 2006 Jul;28(5):500-4
pubmed: 16808879
Haematologica. 2006 Aug;91(8):1017-26
pubmed: 16870554
J Neurosurg Spine. 2006 Nov;5(5):424-33
pubmed: 17120892
Biochem Biophys Res Commun. 2007 Mar 9;354(2):559-66
pubmed: 17234155
Cell Transplant. 2006;15(8-9):675-87
pubmed: 17269439
J Neurotrauma. 2007 Feb;24(2):391-410
pubmed: 17376002
Stem Cells. 2007 Jul;25(7):1761-8
pubmed: 17395769
Shock. 2008 Jan;29(1):49-55
pubmed: 17666954
Neuroreport. 2008 Aug 27;19(13):1259-63
pubmed: 18695504
Transplantation. 2008 Sep 27;86(6):845-53
pubmed: 18813110
Neurosurg Focus. 2008;25(5):E2
pubmed: 18980476
Nat Med. 2009 Apr;15(4):425-35
pubmed: 19270709
Cell Transplant. 2008;17(12):1277-93
pubmed: 19364066
Endocr Rev. 2009 May;30(3):204-13
pubmed: 19366754
J Neurotrauma. 2009 Oct;26(10):1759-71
pubmed: 19413501
J Neurotrauma. 2009 Nov;26(11):2057-69
pubmed: 19469692
Eur J Neurosci. 2009 Sep;30(5):833-46
pubmed: 19712091
Cytotherapy. 2009;11(7):897-911
pubmed: 19903102
J Neurosci. 2009 Nov 25;29(47):14932-41
pubmed: 19940189
J Neurotrauma. 2011 Aug;28(8):1611-82
pubmed: 20146557
Cytotherapy. 2010 Oct;12(6):792-806
pubmed: 20524772
Spine (Phila Pa 1976). 2010 Jul 15;35(16):1520-6
pubmed: 20581748
Prog Neurobiol. 2011 Mar;93(3):341-9
pubmed: 21163325
J Neurosurg Spine. 2011 Jul;15(1):97-106
pubmed: 21456892
J Cell Physiol. 2011 Aug;226(8):2131-8
pubmed: 21520065
Cell Commun Signal. 2011 May 14;9:12
pubmed: 21569606
Atherosclerosis. 2011 Nov;219(1):92-9
pubmed: 21855069
Cytotherapy. 2011 Nov;13(10):1180-92
pubmed: 21899391
Neurosurgery. 2012 May;70(5):1238-47; discussion 1247
pubmed: 22127044
J Control Release. 2012 Apr 30;159(2):271-80
pubmed: 22227024
Nat Biotechnol. 2012 Jan 09;30(1):12-3
pubmed: 22231081
J Neurotrauma. 2012 May 20;29(8):1614-25
pubmed: 22233298
Clin Neurol Neurosurg. 2012 Sep;114(7):935-9
pubmed: 22464434
Neurosurg Rev. 2012 Jul;35(3):293-311; discussion 311
pubmed: 22539011
Indian J Med Res. 2012 Mar;135:287-96
pubmed: 22561613
J Vet Med Sci. 2012 Dec;74(12):1617-30
pubmed: 22878503
Cell. 2012 Sep 14;150(6):1264-73
pubmed: 22980985
J Pathol. 2013 Jan;229(2):332-46
pubmed: 23007711
World Neurosurg. 2014 Jan;81(1):183-90
pubmed: 23022648
PLoS One. 2012;7(9):e45538
pubmed: 23029081
Handb Clin Neurol. 2012;109:485-502
pubmed: 23098732
Prog Brain Res. 2012;201:333-59
pubmed: 23186722
CMAJ. 2013 Apr 2;185(6):485-92
pubmed: 23228995
Expert Opin Drug Deliv. 2013 Mar;10(3):385-96
pubmed: 23289716
Cytotherapy. 2013 Mar;15(3):330-43
pubmed: 23318344
Cell Transplant. 2014 Apr;23(6):729-45
pubmed: 23452836
Cell Mol Life Sci. 2013 Oct;70(20):3871-82
pubmed: 23456256
Cytotherapy. 2013 Jul;15(7):840-9
pubmed: 23623275
Cell Transplant. 2014;23(9):1045-59
pubmed: 23676629
Neurosci Bull. 2013 Aug;29(4):421-35
pubmed: 23861090
Brain Res. 2013 Oct 2;1533:73-9
pubmed: 23948102
Biomed Res Int. 2013;2013:383685
pubmed: 24106704
Stem Cells. 2014 Apr;32(4):829-43
pubmed: 24155224
Prog Neurobiol. 2014 Mar;114:25-57
pubmed: 24269804
Exp Neurol. 2014 Apr;254:121-33
pubmed: 24485983
BMB Rep. 2014 Mar;47(3):135-40
pubmed: 24499672
Cell J. 2014 Summer;16(2):117-130
pubmed: 24567941
Curr Opin Neurobiol. 2014 Aug;27:53-60
pubmed: 24632308
Stem Cells Int. 2014;2014:437521
pubmed: 24723956
Acta Neurochir (Wien). 2014 Jul;156(7):1409-18
pubmed: 24744011
World J Stem Cells. 2014 Apr 26;6(2):120-33
pubmed: 24772239
Cytotherapy. 2014 Aug;16(8):1059-72
pubmed: 24794182
Stem Cells Dev. 2014 Jul 15;23(14):1659-74
pubmed: 24803143
PLoS One. 2014 May 15;9(5):e96020
pubmed: 24830794
Neurochem Res. 2014 Aug;39(8):1544-52
pubmed: 24890008
Neural Regen Res. 2013 Feb 15;8(5):397-403
pubmed: 25206680
Neural Regen Res. 2014 Feb 15;9(4):343-55
pubmed: 25206822
PLoS One. 2014 Oct 07;9(10):e109305
pubmed: 25290916
Stem Cell Res Ther. 2014 Nov 17;5(6):126
pubmed: 25406723
Stem Cell Rev. 2015 Apr;11(2):288-97
pubmed: 25420577
World J Orthop. 2015 Jan 18;6(1):42-55
pubmed: 25621210
Spinal Cord. 2016 Jan;54(1):8-15
pubmed: 26099215
Neurosurgery. 2015 Oct;77(4):604-12; discussion 612
pubmed: 26134596
Cytotherapy. 2015 Oct;17(10):1374-83
pubmed: 26188966
PLoS One. 2015 Aug 06;10(8):e0135111
pubmed: 26248331
Biomaterials. 2016 Jan;75:13-24
pubmed: 26474039
Biomaterials. 2016 Jan;75:135-147
pubmed: 26497428
Stem Cell Res Ther. 2015 Nov 26;6:229
pubmed: 26612085
Mol Cell Proteomics. 2016 Feb;15(2):394-408
pubmed: 26695766
Expert Opin Ther Pat. 2016;26(4):427-37
pubmed: 26726838
Biomaterials. 2016 Mar;83:23-36
pubmed: 26773663
Cell Transplant. 2016;25(8):1425-38
pubmed: 26850705
Neurosurgery. 2016 Mar;78(3):436-47; discussion 447
pubmed: 26891377
Leukemia. 2016 May;30(5):1143-54
pubmed: 26898191
Cytotherapy. 2016 Apr;18(4):518-22
pubmed: 26971680
J Vet Sci. 2016 Mar;17(1):123-6
pubmed: 27051350
Cell Transplant. 2016 Nov;25(11):1925-1943
pubmed: 27075659
Exp Neurol. 2016 Aug;282:66-77
pubmed: 27212626
Neurochem Res. 2016 Oct;41(10):2708-2718
pubmed: 27351200
Mediators Inflamm. 2016;2016:9476020
pubmed: 27418745
Crit Care Med. 2016 Nov;44(11):e1118-e1131
pubmed: 27441900
Stem Cell Res Ther. 2016 Sep 09;7(1):131
pubmed: 27612948
Stem Cells Int. 2016;2016:6901286
pubmed: 27651799
Adv Healthc Mater. 2016 Nov;5(22):2856-2865
pubmed: 27767258
J Inflamm Res. 2016 Dec 15;9:231-240
pubmed: 28008279
Oncotarget. 2017 Feb 14;8(7):10781-10782
pubmed: 28099895
Methods Mol Biol. 2017;1554:201-209
pubmed: 28185193
J Neurotrauma. 2017 Nov 1;34(21):3003-3011
pubmed: 28351209
Saudi J Biol Sci. 2017 Mar;24(3):519-525
pubmed: 28386176
Cytotherapy. 2017 Jul;19(7):839-848
pubmed: 28478920
Front Bioeng Biotechnol. 2017 May 17;5:32
pubmed: 28567372
Stem Cells Int. 2017;2017:5251313
pubmed: 28630630
J Clin Invest. 2017 Sep 1;127(9):3259-3270
pubmed: 28737515
J Chem Neuroanat. 2018 Jan;87:25-31
pubmed: 28803968
Iran J Basic Med Sci. 2017 Apr;20(4):392-398
pubmed: 28804608
Trends Mol Med. 2017 Sep;23(9):831-849
pubmed: 28811172
Int J Mol Sci. 2017 Aug 25;18(9):null
pubmed: 28841158
Pediatr Res. 2018 Jan;83(1-2):214-222
pubmed: 28972960
Sci Rep. 2017 Oct 3;7(1):12605
pubmed: 28974767
Eur J Med Genet. 2018 Feb;61(2):114-118
pubmed: 29079547
Global Spine J. 2017 Sep;7(3 Suppl):95S-115S
pubmed: 29164038
J Cell Physiol. 2018 Aug;233(8):6241-6249
pubmed: 29345324
Physiol Rev. 2018 Apr 1;98(2):881-917
pubmed: 29513146
Int J Mol Sci. 2018 Mar 30;19(4):null
pubmed: 29601528
Stem Cell Res Ther. 2018 May 11;9(1):136
pubmed: 29751769
Cell Transplant. 2018 Jul;27(7):1140-1153
pubmed: 29909686
Cell Transplant. 2018 Jul;27(7):1126-1139
pubmed: 29947256
J Cell Mol Med. 2019 Feb;23(2):1581-1592
pubmed: 30585395
Stem Cell Res Ther. 2019 Jan 11;10(1):19
pubmed: 30635045
Neurosurg Focus. 2019 Mar 1;46(3):E10
pubmed: 30835679
Commun Biol. 2019 Mar 6;2:91
pubmed: 30854483
Mol Neurobiol. 2019 Apr 2;:null
pubmed: 30941733
Stem Cell Res Ther. 2019 Apr 3;10(1):115
pubmed: 30944028
Stem Cells Int. 2019 Apr 1;2019:7627148
pubmed: 31065279