Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes.
Chalcones
Hydrosolubilization of hydrophobic drugs
Nanoparticles
Prostate and colorectal cancer cell lines
β-Cyclodextrin/cellulose nanocrystals
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
02
05
2019
revised:
24
05
2019
accepted:
27
05
2019
pubmed:
5
6
2019
medline:
10
9
2020
entrez:
5
6
2019
Statut:
ppublish
Résumé
This paper describes the preparation of two chalcone/β-cyclodextrin/cellulose-nanocrystals complexes and the study of their antiproliferative activities against two colorectal and two prostatic cancer cell lines. The aim of this work was to enhance hydrosolubility of chalcones thanks to the hydrophilic character of cellulose nanocrystals. These latter were linked, through ionic interactions, to a cationic derivative of β-cyclodextrins whose lipophilic cavity allowed the encapsulation of hydrophobic chalcones: 3-hydroxy-3',4,4',5'-tetramethoxychalcone (1) and 3',4,4',5'-tetramethoxychalcone (2). First, we showed that encapsulation allowed hydrosolubilization of chalcones. Then, chalcone/β-cyclodextrin/cellulose-nanocrystals complexes demonstrated enhanced in vitro antiproliferative activities, compared to the corresponding free-chalcones.
Identifiants
pubmed: 31160179
pii: S0960-894X(19)30362-2
doi: 10.1016/j.bmcl.2019.05.056
pii:
doi:
Substances chimiques
Chalcones
0
beta-Cyclodextrins
0
Cellulose
9004-34-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1895-1898Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.