Intravenous Immunoglobulin Administration Significantly Increases BKPyV Genotype-Specific Neutralizing Antibody Titers in Kidney Transplant Recipients.
BK nephropathy
BK virus
intravenous immunoglobulin
kidney transplantation
viral infection
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
22
02
2019
accepted:
21
05
2019
pubmed:
5
6
2019
medline:
23
6
2020
entrez:
5
6
2019
Statut:
epublish
Résumé
BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is one of the major causes of kidney graft dysfunction, and there are no BKPyV-specific antiviral therapies available. BKPyV neutralizing antibodies (NAbs) play key roles in protecting against BKPyV replication and represent a potential therapeutic or preventive strategy. In this study, we evaluated NAb titers in intravenous immunoglobulin (i.v. Ig) preparations and in kidney transplant recipients (KTR) before and after i.v. Ig administration. NAb titers directed against major BKPyV genotypes were measured using a BKPyV pseudovirion system. Thirty-three KTR receiving high (1 g/kg of body weight/day;
Identifiants
pubmed: 31160292
pii: AAC.00393-19
doi: 10.1128/AAC.00393-19
pmc: PMC6658761
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Immunoglobulins, Intravenous
0
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
Am J Transplant. 2010 Dec;10(12):2615-23
pubmed: 21114642
N Engl J Med. 2002 Aug 15;347(7):488-96
pubmed: 12181403
J Am Soc Nephrol. 2004 Dec;15(12):3256-62
pubmed: 15579530
J Clin Microbiol. 2015 Dec;53(12):3842-52
pubmed: 26468499
PLoS Pathog. 2012;8(4):e1002650
pubmed: 22511874
Transplantation. 2006 Jan 15;81(1):117-20
pubmed: 16421486
Am J Transplant. 2013 Mar;13 Suppl 4:179-88
pubmed: 23465010
Transplantation. 2010 Jun 27;89(12):1462-5
pubmed: 20568674
Clin Microbiol Infect. 2014 Sep;20 Suppl 7:74-88
pubmed: 24476010
Am J Transplant. 2013 Jun;13(6):1474-83
pubmed: 23721552
Am J Transplant. 2006 May;6(5 Pt 1):1025-32
pubmed: 16611340
J Allergy Clin Immunol. 2017 Mar;139(3S):S1-S46
pubmed: 28041678
Pediatr Transplant. 1998 May;2(2):92-105
pubmed: 10082441
N Engl J Med. 2008 Jul 17;359(3):242-51
pubmed: 18635429
J Clin Epidemiol. 2009 Jan;62(1):13-21.e5
pubmed: 18947971
Transplant Direct. 2017 Mar 10;3(4):e142
pubmed: 28405598
J Clin Microbiol. 2014 Dec;52(12):4298-304
pubmed: 25297334
Transplant Proc. 2015 Mar;47(2):394-8
pubmed: 25769580
J Virol. 2013 Sep;87(18):10105-13
pubmed: 23843634
Bone Marrow Transplant. 2014 May;49(5):664-70
pubmed: 24488049
Kidney Int. 2006 Feb;69(4):655-62
pubmed: 16395271
Am J Kidney Dis. 2001 Sep;38(3):E13
pubmed: 11532715
Crit Rev Microbiol. 2017 Mar;43(2):178-195
pubmed: 27800693
Nat Rev Nephrol. 2012 Apr 17;8(7):390-402
pubmed: 22508181
Cancer. 2009 Dec 1;115(23):5371-81
pubmed: 19691089
J Med Virol. 2008 Oct;80(10):1850-7
pubmed: 18712842
Pediatr Transplant. 2009 Feb;13(1):123-9
pubmed: 18822106
Am J Transplant. 2013 Jan;13(1):136-45
pubmed: 23137180
BMJ. 1999 Aug 21;319(7208):508-12
pubmed: 10454409
Pediatr Transplant. 2012 Feb;16(1):E19-24
pubmed: 22248251
Transplantation. 2013 Jun 27;95(12):1498-505
pubmed: 23778568
Clin Infect Dis. 2005 Aug 1;41(3):354-60
pubmed: 16007533
Am J Transplant. 2015 Apr;15(4):1014-20
pubmed: 25736704
Transplantation. 2001 Jan 15;71(1):53-8
pubmed: 11211195
J Am Soc Nephrol. 2018 Jan;29(1):326-334
pubmed: 29042457