Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry.
Antibodies, Monoclonal
/ pharmacology
Cytoplasm
/ virology
Dendritic Cells
/ drug effects
Ebolavirus
/ physiology
Gangliosides
/ metabolism
HIV-1
/ physiology
Hemorrhagic Fever, Ebola
/ virology
Host-Pathogen Interactions
/ drug effects
Humans
Interferon-alpha
/ pharmacology
Lipopolysaccharides
/ pharmacology
Sialic Acid Binding Ig-like Lectin 1
/ antagonists & inhibitors
Virion
/ metabolism
Virus Attachment
/ drug effects
Virus Internalization
/ drug effects
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
12
07
2018
accepted:
11
04
2019
pubmed:
5
6
2019
medline:
22
1
2020
entrez:
5
6
2019
Statut:
ppublish
Résumé
Several Ebola viruses cause outbreaks of lethal haemorrhagic fever in humans, but developing therapies tackle only Zaire Ebola virus. Dendritic cells (DCs) are targets of this infection in vivo. Here, we found that Ebola virus entry into activated DCs requires the sialic acid-binding Ig-like lectin 1 (Siglec-1/CD169), which recognizes sialylated gangliosides anchored to viral membranes. Blockage of the Siglec-1 receptor by anti-Siglec-1 monoclonal antibodies halted Ebola viral uptake and cytoplasmic entry, offering cross-protection against other ganglioside-containing viruses such as human immunodeficiency virus type 1.
Identifiants
pubmed: 31160823
doi: 10.1038/s41564-019-0453-2
pii: 10.1038/s41564-019-0453-2
doi:
Substances chimiques
Antibodies, Monoclonal
0
Gangliosides
0
Interferon-alpha
0
Lipopolysaccharides
0
SIGLEC1 protein, human
0
Sialic Acid Binding Ig-like Lectin 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1558-1570Références
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