Fast calcium transients in dendritic spines driven by extreme statistics.
Animals
Brain
/ metabolism
Calcium
/ metabolism
Calcium Signaling
/ physiology
Computer Simulation
Dendritic Spines
/ metabolism
Endoplasmic Reticulum
/ metabolism
Endoplasmic Reticulum, Smooth
/ metabolism
Hippocampus
/ metabolism
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Neurons
/ physiology
Ryanodine Receptor Calcium Release Channel
/ metabolism
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
17
04
2018
accepted:
08
04
2019
entrez:
5
6
2019
pubmed:
5
6
2019
medline:
14
2
2020
Statut:
epublish
Résumé
Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP production by endoplasmic reticulum-mitochondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes. In dendritic spines receiving synaptic inputs, we show here that in the presence of a spine apparatus (SA), which is an extension of the smooth ER, a calcium-induced calcium release (CICR) is triggered at the base of the spine by the fastest calcium ions arriving at a Ryanodyne receptor (RyR). The mechanism relies on the asymmetric distributions of RyRs and sarco/ER calcium-ATPase (SERCA) pumps that we predict using a computational model and further confirm experimentally in culture and slice hippocampal neurons. The present mechanism for which the statistics of the fastest particles arriving at a small target, followed by an amplification, is likely to be generic in molecular transduction across cellular microcompartments, such as thin neuronal processes, astrocytes, endfeets, or protrusions.
Identifiants
pubmed: 31163024
doi: 10.1371/journal.pbio.2006202
pii: pbio.2006202
pmc: PMC6548358
doi:
Substances chimiques
Ryanodine Receptor Calcium Release Channel
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2006202Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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