Altered thymic CD4
Adult
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ immunology
Case-Control Studies
Female
Hematologic Neoplasms
/ immunology
Hematopoiesis
/ physiology
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immune Reconstitution
/ physiology
Immunity, Cellular
/ physiology
Immunocompromised Host
Male
Middle Aged
Nocardia Infections
/ etiology
Opportunistic Infections
/ etiology
Retrospective Studies
Risk Factors
Thymus Gland
/ immunology
Transplantation Conditioning
/ adverse effects
Transplantation, Homologous
Allogeneic hematopoietic stem cell transplant
Immune recovery
Nocardia
Opportunistic infection
Thymic CD4(+)T-cell
Journal
Current research in translational medicine
ISSN: 2452-3186
Titre abrégé: Curr Res Transl Med
Pays: France
ID NLM: 101681234
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
10
10
2018
revised:
14
05
2019
accepted:
20
05
2019
pubmed:
6
6
2019
medline:
29
8
2020
entrez:
6
6
2019
Statut:
ppublish
Résumé
Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4 This is a case control retrospective monocentric study. We retrospectively analyzed a monocentric cohort of 15 cases of nocardiosis after AHCT and we explored the degree of patients' immunosuppression by phenotyping circulating lymphoid subpopulations, including NK cells, CD8 At onset of nocardiosis, circulating lymphocytes and CD4 Immune recovery monitoring follow-up after AHCT is of particular importance to identify patients susceptible to develop Nocardiosis. Efficient microbiological investigations toward Nocardia such PCR should be used in case of compatible clinical presentation.
Identifiants
pubmed: 31164285
pii: S2452-3186(19)30019-4
doi: 10.1016/j.retram.2019.05.001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-143Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.