Modulation of miRNA function by natural and synthetic RNA-binding proteins in cancer.
Designer RNA-binding proteins
PUF domain
Pentatricopeptide repeat
RNA interference
RNA–protein interactions
Synthetic biology
miRNA
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
05
03
2019
accepted:
28
05
2019
revised:
02
05
2019
pubmed:
6
6
2019
medline:
18
10
2019
entrez:
6
6
2019
Statut:
ppublish
Résumé
RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important regulators of mRNA stability and translation in eukaryotic cells; however, the complex interplay between these systems is only now coming to light. RBPs and miRNAs regulate a unique set of targets in either a positive or negative manner and their regulation is mainly opposed to each other on overlapping targets. In some cases, the levels of RBPs or miRNAs regulate the cellular levels of one another and decreased levels of either results in changes in translation of their targets. There is growing evidence that these regulatory circuits are crucial in the development and progression of cancer; however, the rules underlying synergism and antagonism between miRNAs and RNA-binding proteins remain unclear. Synthetic biology seeks to develop artificial systems to better understand their natural counterparts and to develop new, useful technologies for manipulation of gene expression at the RNA level. The recent development of artificial RNA-binding proteins promises to enable a much greater understanding of the importance of the functional interactions between RNA-binding proteins and miRNAs, as well as enabling their manipulation for therapeutic purposes.
Identifiants
pubmed: 31165201
doi: 10.1007/s00018-019-03163-9
pii: 10.1007/s00018-019-03163-9
doi:
Substances chimiques
MicroRNAs
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3745-3752Subventions
Organisme : National Health and Medical Research Council
ID : APP1058442
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