The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis.
Centromere-pairing
Chromocenter
Heterochromatin
Meiosis
SYCP1
Journal
Chromosoma
ISSN: 1432-0886
Titre abrégé: Chromosoma
Pays: Austria
ID NLM: 2985138R
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
17
12
2018
accepted:
09
05
2019
revised:
02
05
2019
pubmed:
6
6
2019
medline:
1
7
2020
entrez:
6
6
2019
Statut:
ppublish
Résumé
In meiosis, crossovers between homologous chromosomes link them together. This enables them to attach to microtubules of the meiotic spindle as a unit, such that the homologs will be pulled away from one another at anaphase I. Homologous pairs can sometimes fail to become linked by crossovers. In some organisms, these non-exchange partners are still able to segregate properly. In several organisms, associations between the centromeres of non-exchange partners occur in meiotic prophase. These associations have been proposed to promote segregation in meiosis I. But it is unclear how centromere pairing could promote subsequent proper segregation. Here we report that meiotic centromere pairing of chromosomes in mouse spermatocytes allows the formation of an association between chromosome pairs. We find that heterochromatin regions of homologous centromeres remain associated even after centromere-pairing dissolves. Our results suggest the model that, in mouse spermatocytes, heterochromatin maintains the association of homologous centromeres in the absence crossing-over.
Identifiants
pubmed: 31165256
doi: 10.1007/s00412-019-00708-6
pii: 10.1007/s00412-019-00708-6
pmc: PMC6823320
doi:
Substances chimiques
Heterochromatin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
355-367Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM087377
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125803
Pays : United States
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