The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer.
Animals
Colorectal Neoplasms
/ etiology
Disease Models, Animal
Disease Susceptibility
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Immunohistochemistry
Interleukin-1 Receptor-Like 1 Protein
/ genetics
Interleukin-33
/ genetics
Lymphocyte Count
Lymphocytes, Tumor-Infiltrating
/ immunology
Male
Mice
Mice, Knockout
Signal Transduction
T-Lymphocytes, Regulatory
/ immunology
Tumor Microenvironment
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
25
01
2019
accepted:
13
05
2019
revised:
09
05
2019
pubmed:
6
6
2019
medline:
11
4
2020
entrez:
6
6
2019
Statut:
ppublish
Résumé
The composition of immune infiltrates strongly affects the prognosis of patients with colorectal cancer (CRC). Interleukin (IL)-33 and regulatory T cells (Tregs) in the tumor microenvironment have been separately implicated in CRC; however their contribution to intestinal carcinogenesis is still controversial. Here, we reveal that IL-33 signaling promotes CRC by changing the phenotype of Tregs. In mice with CRC, tumor-infiltrating Tregs preferentially upregulate IL-33 receptor (ST2), and IL-33/ST2 signaling positively correlates with tumor number and size. Transcriptomic and flow cytometry analyses demonstrate that ST2 expression induces a more activated and migratory phenotype in FOXP3
Identifiants
pubmed: 31165767
doi: 10.1038/s41385-019-0176-y
pii: S1933-0219(22)00277-X
pmc: PMC7746527
doi:
Substances chimiques
Il1rl1 protein, mouse
0
Interleukin-1 Receptor-Like 1 Protein
0
Interleukin-33
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
990-1003Références
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