The plant product quinic acid activates Ca
Actinidia
/ chemistry
Animals
Biological Products
/ chemistry
Calcium
/ metabolism
Cells, Cultured
Coffee
/ chemistry
Dose-Response Relationship, Drug
Hippophae
/ chemistry
Insulin Secretion
/ drug effects
Insulin-Secreting Cells
/ drug effects
Male
Mice
Mice, Inbred C57BL
Mitochondria
/ drug effects
Prunus
/ chemistry
Quinic Acid
/ chemistry
Rats
Structure-Activity Relationship
Vaccinium macrocarpon
/ chemistry
Vaccinium myrtillus
/ chemistry
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
09
11
2018
revised:
07
04
2019
accepted:
04
05
2019
pubmed:
6
6
2019
medline:
29
8
2020
entrez:
6
6
2019
Statut:
ppublish
Résumé
Quinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta-cell functions, which contribute to the control of metabolic health by lowering blood glucose. Strategies targeting beta-cell signal transduction are a new approach for diabetes treatment. This study investigated the efficacy of QA to stimulate beta-cell function by targeting the basic molecular machinery of metabolism-secretion coupling. We measured bioenergetic parameters and insulin exocytosis in a model of insulin-secreting beta-cells (INS-1E), together with Ca QA triggered transient cytosolic Ca QA modulated intracellular Ca
Sections du résumé
BACKGROUND AND PURPOSE
Quinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta-cell functions, which contribute to the control of metabolic health by lowering blood glucose. Strategies targeting beta-cell signal transduction are a new approach for diabetes treatment. This study investigated the efficacy of QA to stimulate beta-cell function by targeting the basic molecular machinery of metabolism-secretion coupling.
EXPERIMENTAL APPROACH
We measured bioenergetic parameters and insulin exocytosis in a model of insulin-secreting beta-cells (INS-1E), together with Ca
KEY RESULTS
QA triggered transient cytosolic Ca
CONCLUSIONS AND IMPLICATIONS
QA modulated intracellular Ca
Identifiants
pubmed: 31166006
doi: 10.1111/bph.14757
pmc: PMC6692587
doi:
Substances chimiques
Biological Products
0
Coffee
0
Quinic Acid
058C04BGYI
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3250-3263Informations de copyright
© 2019 The British Pharmacological Society.
Références
Biochem J. 2015 Mar 1;466(2):203-18
pubmed: 25697093
Crit Rev Food Sci Nutr. 2011 Jul;51(6):524-46
pubmed: 21929330
Trends Cell Biol. 2009 Feb;19(2):81-8
pubmed: 19144519
Adv Healthc Mater. 2017 Feb;6(4):
pubmed: 27995762
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17404-9
pubmed: 15585581
J Cell Biochem. 1997 Mar 1;64(3):414-22
pubmed: 9057099
J Nutr. 2001 Jan;131(1):66-71
pubmed: 11208940
Mol Cell. 2010 Apr 23;38(2):280-90
pubmed: 20417605
Diabetes. 2003 Jan;52(1):102-10
pubmed: 12502499
Endocrinology. 2003 Aug;144(8):3565-74
pubmed: 12865339
Nat Rev Drug Discov. 2014 Apr;13(4):278-89
pubmed: 24525781
Diabetes. 2011 Oct;60(10):2533-45
pubmed: 21885870
Evid Based Complement Alternat Med. 2015;2015:629863
pubmed: 26587047
Food Chem Toxicol. 2014 Sep;71:183-96
pubmed: 24953551
Physiol Rev. 2018 Jan 1;98(1):117-214
pubmed: 29212789
J Assoc Off Anal Chem. 1978 Nov;61(6):1490-2
pubmed: 730655
J Endocrinol. 1999 Mar;160(3):409-14
pubmed: 10076186
J Agric Food Chem. 2002 Jan 2;50(1):113-6
pubmed: 11754553
Cell Metab. 2011 May 4;13(5):601-11
pubmed: 21531342
PLoS One. 2017 Aug 10;12(8):e0180808
pubmed: 28796787
J Clin Invest. 2015 May;125(5):1968-78
pubmed: 25844899
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
J Pharmacol Exp Ther. 2006 Aug;318(2):476-83
pubmed: 16644902
Br J Pharmacol. 2017 Dec;174 Suppl 1:S160-S194
pubmed: 29055033
Clin Sci (Lond). 2017 Feb 1;131(3):247-260
pubmed: 27980130
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10554-9
pubmed: 15247428
J Biol Chem. 2004 Oct 1;279(40):41361-7
pubmed: 15220351
Br J Pharmacol. 2017 Dec;174 Suppl 1:S272-S359
pubmed: 29055034
Diabetes Care. 2003 Mar;26(3):832-6
pubmed: 12610045
J Cell Sci. 2017 Jun 1;130(11):1929-1939
pubmed: 28404787
Chem Biol. 2006 May;13(5):521-30
pubmed: 16720273
Br J Pharmacol. 2010 Aug;160(7):1577-9
pubmed: 20649561
Diabetes Obes Metab. 2014 Jul;16(7):602-12
pubmed: 24205999
Adv Healthc Mater. 2018 Apr;7(8):e1701148
pubmed: 29283209
Asian Pac J Trop Biomed. 2012 Apr;2(4):320-30
pubmed: 23569923
Oxid Med Cell Longev. 2012;2012:932838
pubmed: 23304259
Phytother Res. 2009 Mar;23(3):335-46
pubmed: 18844285
J Biol Chem. 2014 Mar 28;289(13):9182-94
pubmed: 24554722
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10857-62
pubmed: 10485916
Bioorg Med Chem Lett. 2013 Apr 1;23(7):2140-4
pubmed: 23462643
J Agric Food Chem. 2012 Oct 24;60(42):10406-14
pubmed: 23033879
IUBMB Life. 2000 Jul;50(1):27-31
pubmed: 11087117
Cell Metab. 2010 May 5;11(5):349-52
pubmed: 20444416
Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun;50:473-503
pubmed: 15012217
Cell Calcium. 2014 Nov;56(5):340-61
pubmed: 25239387
Sci Rep. 2017 Jul 17;7(1):5611
pubmed: 28717166
Diabetes. 1999 Dec;48(12):2398-406
pubmed: 10580429
Evid Based Complement Alternat Med. 2013;2013:801457
pubmed: 24062792
Diabetes. 2004 Dec;53 Suppl 3:S16-21
pubmed: 15561905
Br J Pharmacol. 2017 Dec;174 Suppl 1:S17-S129
pubmed: 29055040
World J Biol Chem. 2015 Nov 26;6(4):310-23
pubmed: 26629314
Mol Cell Endocrinol. 2012 Apr 28;353(1-2):128-37
pubmed: 21784130
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5203-7
pubmed: 10792038
Biomed Pharmacother. 2017 Dec;96:563-571
pubmed: 29032340
Cell Calcium. 2012 Mar-Apr;51(3-4):300-8
pubmed: 22177710
FASEB J. 2016 May;30(5):1913-26
pubmed: 26839375
Br J Pharmacol. 2019 Sep;176(17):3250-3263
pubmed: 31166006
Cell Calcium. 2008 Jul;44(1):64-76
pubmed: 18191448
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9198-203
pubmed: 20439740