Human Colorectal Carcinoma Infiltrating B Lymphocytes Are Active Secretors of the Immunoglobulin Isotypes A, G, and M.
B cells
FluoroSpot
colorectal carcinoma
tumor infiltrating lymphocytes
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Jun 2019
04 Jun 2019
Historique:
received:
10
04
2019
revised:
14
05
2019
accepted:
29
05
2019
entrez:
7
6
2019
pubmed:
7
6
2019
medline:
7
6
2019
Statut:
epublish
Résumé
Despite the importance of tumor infiltrating B cells (TiBc) in immunological circuits, their functional role is scarcely investigated. Here, we analyzed immunoglobulin (Ig) secretion of the subtypes IgA, IgG, and IgM of TiBc from freshly resected primary and secondary colorectal carcinomas (CRC) by FluoroSpot (
Identifiants
pubmed: 31167511
pii: cancers11060776
doi: 10.3390/cancers11060776
pmc: PMC6627757
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Immunol Rev. 1999 Oct;171:45-87
pubmed: 10582165
Cancer Res. 2003 Jun 15;63(12):3275-80
pubmed: 12810659
Anticancer Res. 1992 Sep-Oct;12(5):1463-6
pubmed: 1332579
Oncogene. 2010 Feb 25;29(8):1093-102
pubmed: 19946335
J Immunol. 2010 Nov 1;185(9):4977-82
pubmed: 20962266
Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
PLoS One. 2012;7(2):e32639
pubmed: 22393427
Clin Cancer Res. 2012 Jun 15;18(12):3281-92
pubmed: 22553348
World J Gastroenterol. 2013 Jan 7;19(1):8-11
pubmed: 23326156
Immunity. 2013 Oct 17;39(4):782-95
pubmed: 24138885
Oncotarget. 2014 Jul 15;5(13):4651-64
pubmed: 25026291
J Clin Oncol. 2016 Apr 20;34(12):e110-6
pubmed: 25348001
Clin Cancer Res. 2016 Jun 15;22(12):3005-15
pubmed: 26763251
Sci Rep. 2016 Apr 18;6:24671
pubmed: 27087592
Oncoimmunology. 2017 Mar 3;6(4):e1294296
pubmed: 28507802
Front Immunol. 2019 Mar 27;10:542
pubmed: 30972056