Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors.
calcium ionophore A23187
glycoproteins IIbIIIa and Ibα receptors of fibrinogen and von Willebrand factor
platelet apoptosis without death receptors
pro-apoptotic BH3 mimetic ABT-737
protease-activated receptor-1 (PAR-1) of thrombin
Journal
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
ISSN: 1938-2723
Titre abrégé: Clin Appl Thromb Hemost
Pays: United States
ID NLM: 9508125
Informations de publication
Date de publication:
Historique:
entrez:
7
6
2019
pubmed:
7
6
2019
medline:
31
12
2019
Statut:
ppublish
Résumé
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane. In this review, we present evidence that, in contrast to nucleated cells, apoptosis in anucleate platelets can be induced through bypassing the death receptors, using instead specific receptors on the platelet surface mediating platelet activation, aggregation, and blood coagulation. These platelet surface receptors include the protease-activated receptor 1 of thrombin and glycoproteins IIbIIIa and Ibα, receptors of fibrinogen, and von Willebrand factor. The pro-apoptotic BH3 mimetic ABT-737 and calcium ionophore A23187 also trigger platelet apoptosis without using death receptors. These agents induce the intrinsic pathway of platelet apoptosis by direct targeting mitochondrial and extra-mitochondrial apoptotic responses.
Identifiants
pubmed: 31167567
doi: 10.1177/1076029619853641
pmc: PMC6715000
doi:
Substances chimiques
Platelet Membrane Glycoproteins
0
Receptors, Cell Surface
0
Receptors, Death Domain
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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