Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells.

Breast Neoplasms / enzymology CRISPR-Cas Systems Cell Line, Tumor Cell Membrane / enzymology Enzyme Inhibitors / pharmacology Female Humans Isoenzymes / antagonists & inhibitors Neoplasm Invasiveness Neoplasm Metastasis RNA, Messenger / genetics Vacuolar Proton-Translocating ATPases / antagonists & inhibitors
a-subunit isoforms breast cancer cell invasion cell migration metastasis plasma membrane protein trafficking proton pump vacuolar ATPase

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
19 07 2019
Historique:
received: 24 01 2019
revised: 30 05 2019
pubmed: 7 6 2019
medline: 3 4 2020
entrez: 7 6 2019
Statut: ppublish

Résumé

The vacuolar H

Identifiants

DOI: 10.1074/jbc.RA119.007713 PMID: 31167791 PMC: PMC6643023
pubmed: 31167791
pii: S0021-9258(20)30251-9
doi: 10.1074/jbc.RA119.007713
pmc: PMC6643023
doi:

Substances chimiques

Enzyme Inhibitors 0
Isoenzymes 0
RNA, Messenger 0
Vacuolar Proton-Translocating ATPases EC 3.6.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11248-11258

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM034478
Pays : United States

Informations de copyright

© 2019 McGuire et al.

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Auteurs

Christina M McGuire (CM)

Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Tufts University, Boston, Massachusetts 02111.
Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111.

Michael P Collins (MP)

Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Tufts University, Boston, Massachusetts 02111.
Program in Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111.

GeHong Sun-Wada (G)

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College, Kyotanabe, Kyoto 610-0395, Japan.

Yoh Wada (Y)

Division of Biological Science, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.
ORCID: 0000-0002-7783-7680

Michael Forgac (M)

Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Tufts University, Boston, Massachusetts 02111 michael.forgac@tufts.edu.
Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111.
Program in Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Isoform-specific gene disruptions reveal a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Proton-Translocating ATPases › Vacuolar Proton-Translocating ATPases › Isoform-specific gene disruptions reveal a...