Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase.

Humans Mitochondrial Proteins / chemistry Nitric Oxide / biosynthesis Nitrites / chemistry Oxidation-Reduction Oxidoreductases Acting on Sulfur Group Donors / chemistry
mitochondria molybdenum cofactor nitric oxide nitrite reduction sulfite oxidase

Journal

The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R

Informations de publication

Date de publication:
28 06 2019
Historique:
received: 26 02 2019
revised: 21 05 2019
accepted: 05 06 2019
pubmed: 7 6 2019
medline: 12 2 2020
entrez: 7 6 2019
Statut: epublish

Résumé

In addition to nitric oxide (NO) synthases, molybdenum-dependent enzymes have been reported to reduce nitrite to produce NO. Here, we report the stoichiometric reduction in nitrite to NO by human sulfite oxidase (SO), a mitochondrial intermembrane space enzyme primarily involved in cysteine catabolism. Kinetic and spectroscopic studies provide evidence for direct nitrite coordination at the molybdenum center followed by an inner shell electron transfer mechanism. In the presence of the physiological electron acceptor cytochrome

Identifiants

DOI: 10.1042/BCJ20190143 PMID: 31167903
pubmed: 31167903
pii: BCJ20190143
doi: 10.1042/BCJ20190143
doi:

Substances chimiques

Mitochondrial Proteins 0
Nitrites 0
Nitric Oxide 31C4KY9ESH
Oxidoreductases Acting on Sulfur Group Donors EC 1.8.-
SUOX protein, human EC 1.8.3.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1805-1815

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Auteurs

Daniel Bender (D)

Department of Chemistry, Institute for Biochemistry, University of Cologne, 50674 Cologne, Germany.
Center for Molecular Medicine Cologne, CMMC, University of Cologne, 50931 Cologne, Germany.

Alexander Tobias Kaczmarek (A)

Department of Chemistry, Institute for Biochemistry, University of Cologne, 50674 Cologne, Germany.
Center for Molecular Medicine Cologne, CMMC, University of Cologne, 50931 Cologne, Germany.

Dimitri Niks (D)

Department of Biochemistry, University of California, Riverside, CA 92521, U.S.A.

Russ Hille (R)

Department of Biochemistry, University of California, Riverside, CA 92521, U.S.A.

Guenter Schwarz (G)

Department of Chemistry, Institute for Biochemistry, University of Cologne, 50674 Cologne, Germany gschwarz@uni-koeln.de.
Center for Molecular Medicine Cologne, CMMC, University of Cologne, 50931 Cologne, Germany.
Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, CECAD, University of Cologne, 50931 Cologne, Germany.
ORCID: 0000-0002-2118-9338

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanism of nitrite-dependent NO synthesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Mechanism of nitrite-dependent NO synthesis by...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Mechanism of nitrite-dependent NO synthesis by...
questionsmedicales.fr › Composés chimiques organiques › Nitrites › Mechanism of nitrite-dependent NO synthesis by...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Mechanism of nitrite-dependent NO synthesis by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on sulfur group donors › Mechanism of nitrite-dependent NO synthesis by...