Simian Immunodeficiency Virus Infection Modulates CD94
Animals
Biomarkers
Cell Line
Host-Pathogen Interactions
/ immunology
Immunophenotyping
Killer Cells, Natural
/ immunology
Lymphocyte Subsets
/ immunology
Macaca mulatta
NK Cell Lectin-Like Receptor Subfamily C
/ metabolism
NK Cell Lectin-Like Receptor Subfamily D
/ metabolism
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ immunology
human immunodeficiency virus
natural killer cells
simian immunodeficiency virus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
10
05
2019
accepted:
03
06
2019
pubmed:
7
6
2019
medline:
4
6
2020
entrez:
7
6
2019
Statut:
epublish
Résumé
Recently, we and others have shown that natural killer (NK) cells exhibit memory-like recall responses against cytomegalovirus (CMV) and human immunodeficiency/virus simian immunodeficiency virus (HIV/SIV) infections. Although the mechanism(s) have not been fully delineated, several groups have shown that the activating receptor NKG2C is elevated on NK cells in the context of rhesus CMV (rhCMV) or human CMV (hCMV) infections. CD94, which heterodimerizes with NKG2C is also linked to adaptive NK cell responses. Because nonhuman primates (NHP) play a crucial role in modeling HIV (SIV) infections, it is crucial to be able to assess and characterize the NKG2 family in NHP. Unfortunately, it is not possible to detect CD94 using commercially available antibodies in NHP. Our work, a first for NHP, has focused on developing RNA flow cytometry using mRNA transcripts as proxies distinguishing NKG2C from NKG2A. We have expanded the application of this technology and here we show the first characterization of CD94
Identifiants
pubmed: 31167916
pii: JVI.00731-19
doi: 10.1128/JVI.00731-19
pmc: PMC6675877
pii:
doi:
Substances chimiques
Biomarkers
0
KLRD1 protein, human
0
NK Cell Lectin-Like Receptor Subfamily C
0
NK Cell Lectin-Like Receptor Subfamily D
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007387
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI120756
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143457
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120828
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI060354
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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