Organoids are promising tools for species-specific in vitro toxicological studies.
Animals
Biotechnology
/ methods
Cattle
Cell Culture Techniques
Chickens
Dogs
Embryonic Stem Cells
/ cytology
Humans
In Vitro Techniques
Induced Pluripotent Stem Cells
/ cytology
Models, Biological
Organ Specificity
Organoids
/ cytology
Pluripotent Stem Cells
/ cytology
Species Specificity
Swine
Toxicity Tests
/ methods
3D models
ESCs
iPSCs
organoids
spheroids
stem cells
toxicology
Journal
Journal of applied toxicology : JAT
ISSN: 1099-1263
Titre abrégé: J Appl Toxicol
Pays: England
ID NLM: 8109495
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
02
03
2019
revised:
05
04
2019
accepted:
05
04
2019
pubmed:
7
6
2019
medline:
30
10
2020
entrez:
7
6
2019
Statut:
ppublish
Résumé
Organoids are three-dimensional self-aggregating structures generated from stem cells (SCs) or progenitor cells in a process that recapitulates molecular and cellular stages of early organ development. The differentiation process leads to the appearance of specialized mature cells and is connected with changes in the organoid internal structure rearrangement and self-organization. The formation of organ-specific structures in vitro with highly ordered architecture is also strongly influenced by the extracellular matrix. These features make organoids as a powerful model for in vitro toxicology. Nowadays this technology is developing very quickly. In this review we present, from a toxicological and species-specific point of view, the state of the art of organoid generation from adult SCs and pluripotent SCs: embryonic SCs or induced pluripotent SCs. The current culture organoid techniques are discussed for their main advantages, disadvantages and limitations. In the second part of the review, we concentrated on the characterization of species-specific organoids generated from tissue-specific SCs of different sources: mammary (bovine), epidermis (canine), intestinal (porcine, bovine, canine, chicken) and liver (feline, canine).
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1610-1622Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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