Scalable Fabrication of Porous Microchannel Nerve Guidance Scaffolds with Complex Geometries.
3D printing
nerve guidance scaffolds
nerve repair
porous fibers
thermal drawing
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
30
03
2019
revised:
15
05
2019
pubmed:
7
6
2019
medline:
7
6
2019
entrez:
7
6
2019
Statut:
ppublish
Résumé
Microchannel scaffolds accelerate nerve repair by guiding growing neuronal processes across injury sites. Although geometry, materials chemistry, stiffness, and porosity have been shown to influence nerve growth within nerve guidance scaffolds, independent tuning of these properties in a high-throughput manner remains a challenge. Here, fiber drawing is combined with salt leaching to produce microchannels with tunable cross sections and porosity. This technique is applicable to an array of biochemically inert polymers, and it delivers hundreds of meters of porous microchannel fibers. Employing these fibers as filaments during 3D printing enables the production of microchannel scaffolds with geometries matching those of biological nerves, including branched topographies. Applied to sensory neurons, fiber-based porous microchannels enhance growth as compared to non-porous channels with matching materials and geometries. The combinatorial scaffold fabrication approach may advance the studies of neural regeneration and accelerate the development of nerve repair devices.
Identifiants
pubmed: 31168865
doi: 10.1002/adma.201902021
pmc: PMC6663568
mid: NIHMS1034729
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1902021Subventions
Organisme : NINDS NIH HHS
ID : R01 NS086804
Pays : United States
Organisme : National Institute of Neurological Disorders and Stroke
ID : 5R01NS086804
Organisme : U.S. Army Research Office through the Institute for Soldier Nanotechnologies
ID : W911NF-13-D-0001
Organisme : National Science Foundation Center for Materials Science and Engineering
ID : DMR-1419807
Organisme : NSF Center for Neurotechnology
ID : EEC-1028725
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
Chem Soc Rev. 2017 Jan 23;46(2):481-558
pubmed: 27906387
Biomed Mater. 2018 Jun 04;13(5):050201
pubmed: 29864020
Acta Biomater. 2016 Sep 15;42:18-32
pubmed: 27370907
Nat Neurosci. 2017 Apr;20(4):612-619
pubmed: 28218915
Adv Mater. 2012 Aug 16;24(31):4311-6
pubmed: 22730266
Nat Commun. 2017 Nov 10;8(1):1435
pubmed: 29127280
Biomaterials. 2013 Sep;34(29):7086-96
pubmed: 23791502
Injury. 2012 May;43(5):553-72
pubmed: 21269624
Biomaterials. 2010 Sep;31(26):6719-29
pubmed: 20619785
Nat Biotechnol. 2015 Mar;33(3):277-84
pubmed: 25599177
Adv Mater. 2017 Jun;29(22):
pubmed: 28306168
Tissue Eng Part B Rev. 2013 Dec;19(6):485-502
pubmed: 23672709
Acta Biomater. 2010 Jul;6(7):2467-76
pubmed: 20144914
Nat Commun. 2017 Aug 28;8(1):364
pubmed: 28848237
Nat Med. 2019 Feb;25(2):263-269
pubmed: 30643285
Biomaterials. 2012 Feb;33(5):1618-26
pubmed: 22130565
J Biomed Mater Res. 1997 Sep 5;36(3):337-46
pubmed: 9260105
J Biomed Mater Res A. 2006 Oct;79(1):36-46
pubmed: 16758450
Int J Bioprint. 2017 Dec 20;4(1):123
pubmed: 33102907
Tissue Eng. 2006 Oct;12(10):2777-87
pubmed: 17518647
Nat Rev Neurosci. 2016 Apr;17(4):224-38
pubmed: 26935168
Adv Funct Mater. 2015 Oct 21;25(39):6205-6217
pubmed: 26924958
Chem Soc Rev. 2017 Jun 6;46(11):3104-3107
pubmed: 28561090
Biomaterials. 1996 Jan;17(2):83-91
pubmed: 8624400
Adv Mater. 2019 Jan;31(1):e1802348
pubmed: 30272829
ACS Biomater Sci Eng. 2016 Oct 10;2(10):1679-1693
pubmed: 28025653
Bioresour Technol. 2015 Nov;195:202-9
pubmed: 26026232
Acta Biomater. 2011 Jul;7(7):2826-34
pubmed: 21521659
Eur Cell Mater. 2003 Jun 30;5:29-39; discussion 39-40
pubmed: 14562270
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Feb;87(2):022111
pubmed: 23496464
Biofabrication. 2018 Mar 23;10(3):032001
pubmed: 29570458
Trends Biotechnol. 2004 Feb;22(2):80-6
pubmed: 14757042
Nat Rev Neurol. 2013 Dec;9(12):668-76
pubmed: 24217518
Biomaterials. 2008 Jul;29(21):3117-27
pubmed: 18448163
Biomaterials. 2016 Mar;81:27-35
pubmed: 26717246
Biomaterials. 2006 Jul;27(19):3515-8
pubmed: 16533522
Biomaterials. 2012 Nov;33(32):8034-9
pubmed: 22889485