Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis.
4-Chloro-7-nitrobenzofurazan
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Benzamides
/ chemistry
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors
/ chemical synthesis
Glutathione S-Transferase pi
/ antagonists & inhibitors
Humans
Hydrolysis
Models, Molecular
Molecular Structure
Structure-Activity Relationship
A375 human melanoma
GSTP1-1
Nitrobenzoxadiazoles
TRAF2
glutathione
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
7
6
2019
pubmed:
7
6
2019
medline:
21
6
2019
Statut:
ppublish
Résumé
The antitumor agent 6-((7-nitrobenzo[
Identifiants
pubmed: 31169043
doi: 10.1080/14756366.2019.1617287
pmc: PMC6566875
doi:
Substances chimiques
Antineoplastic Agents
0
Benzamides
0
Enzyme Inhibitors
0
benzamide
6X80438640
Glutathione S-Transferase pi
EC 2.5.1.18
4-Chloro-7-nitrobenzofurazan
EQF2794IRE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1131-1139Références
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